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| Other Sizes |
| Targets |
3-Hydroxy-2-methylpyridine does not have a specific biological target as it is primarily a chemical intermediate and impurity. The compound is used in the preparation of substituted pyridine and pyrimidine derivatives for treating viral infections. Its role as a molecular scaffold suggests potential for developing novel inhibitors of protein fibrillization.
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| ln Vitro |
In vitro activity of 3-hydroxy-2-methylpyridine is demonstrated by its utility as a chemical intermediate in the synthesis of bioactive compounds. The compound is used in the preparation of pyrimidines and other heterocyclic compounds with potential antiviral activity. Its activity as a molecular scaffold for fibrillization inhibitors suggests potential for therapeutic applications.
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| ln Vivo |
In vivo activity of 3-hydroxy-2-methylpyridine is not extensively documented, as the compound is primarily a chemical intermediate and impurity rather than a therapeutic agent. Its role as an impurity of Pantoprazole suggests that it may be present in trace amounts following drug administration.
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| Enzyme Assay |
In vitro enzyme assays for 3-hydroxy-2-methylpyridine are not typically performed, as it is a chemical intermediate rather than a pharmacologically active compound. The compound's role in the enzymatic conversion of 5-formyl-3-hydroxy-2-methylpyridine to other products has been documented.
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| Cell Assay |
In vitro cellular assays are not applicable to 3-hydroxy-2-methylpyridine, as it is primarily used as a chemical intermediate for synthesis rather than as a bioactive compound tested directly on cells.
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| Animal Protocol |
In vivo animal experiments for 3-hydroxy-2-methylpyridine are not extensively documented. As an impurity of Pantoprazole, the compound may be present in animal models following drug administration, but its pharmacological effects are not characterized.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 3-hydroxy-2-methylpyridine are not well characterized, as it is primarily a chemical intermediate rather than a therapeutic agent. Its physicochemical properties include a relative density of 1.12 g/cm³. The compound is a beige-brown powder.
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| Toxicity/Toxicokinetics |
Toxicological data for 3-hydroxy-2-methylpyridine are limited. As a chemical intermediate and impurity, comprehensive toxicological studies have not been reported. Standard laboratory safety precautions should be followed when handling this compound.
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| References |
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| Additional Infomation |
3-Hydroxy-2-methylpyridine is a methylpyridine compound. It has been reported that 3-hydroxy-2-methylpyridine is found in Streptomyces, Astragalus membranaceus, and Sage, and relevant data are available for reference.
3-Hydroxy-2-methylpyridine (CAS#: 1121-25-1) has the molecular formula C6H7NO and a molecular weight of 109.13. It is also known as 3-Hydroxy-2-picoline or 2-Methyl-3-pyridinol. Purity is >98.0%. The compound is extracted from theobromine extract and used as a chemical intermediate for pyrimidine synthesis. |
| Molecular Formula |
C6H7NO
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|---|---|
| Molecular Weight |
109.13
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| Exact Mass |
109.052
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| CAS # |
1121-25-1
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| PubChem CID |
70719
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| Appearance |
Off-white to light brown solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
287.1±20.0 °C at 760 mmHg
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| Melting Point |
168-169 °C(lit.)
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| Flash Point |
127.4±21.8 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.551
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| Source |
Originated from plants: Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao
Originated from plants: other families |
| LogP |
1.1
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
8
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| Complexity |
74.9
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC1=NC=CC=C1O
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| InChi Key |
AQSRRZGQRFFFGS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H7NO/c1-5-6(8)3-2-4-7-5/h2-4,8H,1H3
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| Chemical Name |
2-methylpyridin-3-ol
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| Synonyms |
3-Hydroxy-2-methylpyridine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~916.3 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (45.82 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (45.82 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 5 mg/mL (45.82 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.1634 mL | 45.8169 mL | 91.6338 mL | |
| 5 mM | 1.8327 mL | 9.1634 mL | 18.3268 mL | |
| 10 mM | 0.9163 mL | 4.5817 mL | 9.1634 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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