E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82396	BzNH-BS	2443928-42-3	BzNH-BS contains two different ligands, MeBS and benzoyl-amide.
V82512	Cbz-PEG5-Br	2710803-69-1	Cbz-PEG5-Br is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82484	CC-3060	444288-86-2	CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation.
V82518	Chloro-PEG2-Boc	1442085-43-9	Chloro-PEG2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82471	CHO-CH2-PEG1-CH2-Boc	2230956-95-1	CHO-CH2-PEG1-CH2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78784	cIAP1 Ligand-Linker Conjugates 10 (E3 ligase Ligand-Linker Conjugates 47)		cIAP1 Ligand-Linker Conjugates 10 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases.
V77903	cIAP1 Ligand-Linker Conjugates 13 (E3 ligase Ligand-Linker Conjugates 43)		cIAP1 Ligand-Linker Conjugates 13 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases.
V82447	cIAP1 Ligand-Linker Conjugates 16	2143956-63-0	cIAP1 Ligand-Linker Conjugates 16 are E3 ligase ligand-linker conjugates for the synthesis of PROTACs.
V78785	cIAP1 Ligand-Linker Conjugates 2 Hydrochloride (E3 ligase Ligand-Linker Conjugates 37 Hydrochloride)		cIAP1 Ligand-Linker Conjugates 2 HCl Contains cIAP ligand and linker for recruitment of E3 ubiquitin ligase.
V78786	cIAP1 Ligand-Linker Conjugates 4 (E3 ligase Ligand-Linker Conjugates 42)		cIAP1 Ligand-Linker Conjugates 4 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases.
V78787	cIAP1 Ligand-Linker Conjugates 6 hydrochloride (E3 ligase Ligand-Linker Conjugates 35 hydrochloride)		cIAP1 Ligand-Linker Conjugates 6 HCl Contains cIAP ligand and linker for recruitment of E3 ubiquitin ligase.
V78788	cIAP1 Ligand-Linker Conjugates 7 (E3 ligase Ligand-Linker Conjugates 44)		cIAP1 Ligand-Linker Conjugates 7 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases.
V77904	cIAP1 Ligand-Linker Conjugates 8 (E3 ligase Ligand-Linker Conjugates 46)		cIAP1 Ligand-Linker Conjugates 8 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases.
V77921	cIAP1 Ligand-Linker Conjugates 9 (E3 ligase Ligand-Linker Conjugates 45)		cIAP1 Ligand-Linker Conjugates 9 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases.
V82418	Cl-PEG4-acid	158553-98-1	Cl-PEG4-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82343	CP5V	2509359-75-3	CP5V is a PROTAC linked by von Hippel-Lindau ligand and CDK ligand, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination and proteasomal degradation.
V82474	CRBNligand-9	55003-81-1	CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM).
V82416	DBCO-NHCO-PEG2-maleimide	2698339-31-8	DBCO-NHCO-PEG2-maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82480	Decaethylene glycol dodecyl ether (PEG10-dodecyl)	618113-48-7	Decaethylene glycol dodecyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82509	Dimethylamino-PEG2-C2-NH2	692782-62-0	Dimethylamino-PEG2-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.