PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82758	(+)-Biotin-PEG2-hydrazide	2413847-26-2	(+)-Biotin-PEG2-hydrazide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82861	(E)-TCO-PEG4-NHS ester	1621096-79-4	(E)-TCO-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82748	(R)-Pomalidomide-pyrrolidine	2418618-52-5	(R)-Pomalidomide-pyrrolidine, a CRBN ligand, can be linked to protein ligands through linkers to produce PROTACs.
V79359	(R)-TCO4-PEG2-Maleimide		TCO4-PEG2-Maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V80303	(R)-TCO4-PEG2-NH2		(R)-TCO4-PEG2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V79045	(R)-TCO4-PEG3-Maleimide		TCO4-PEG3-Maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V78842	(R)-TCO4-PEG7-NH2		(R)-TCO4-PEG7-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82641	(Rac)-PROTAC PARP/EGFR ligand 1	2935073-36-0	(Rac)-PROTAC PARP/EGFR ligand 1 Contains ligands for the target proteins PARP and EGFR, and a PROTAC (PROteolysis TArgeting Chimera) linker that recruits E3 ligases such as VHL, CRBN, MDM2, and IAP.
V79046	(S)-TCO-PEG3-maleimide		(S)-TCO-PEG3-maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V79980	(S,E)-TCO2-PEG3-acid		(S)-TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid (COOH) group.
V78486	(S,E)-TCO2-PEG8-acid		(S)-TCO-PEG8-acid is a click chemistry PEG linker with a terminal carboxylic acid (COOH) group.
V82909	(S,R,S)-AHPC-amido-C7-acid	2172819-76-8	(S,R,S)-AHPC-amido-C7-acid contains VHL ligand and PROTAC (PROteolysis TArgeting Chimera) linker for recruitment of E3 ubiquitin ligase.
V82905	(S,R,S)-AHPC-C1-Br	2379404-33-6	(S,R,S)-AHPC-C1-Br is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker, which may be utilized to prepare PROTAC molecules.
V82855	(S,R,S)-AHPC-C1-NH2	2010986-20-4	(S,R,S)-AHPC-C1-NH2 is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker, which may be utilized to prepare PROTAC molecules.
V82638	(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2)	2341796-74-3	(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R ,S)-AHPC VHL ligand and 1 linker.
V82708	(S,R,S)-AHPC-C2-NH2	2241643-69-4	(S,R,S)-AHPC-C2-NH2 is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker, which may be utilized to prepare PROTAC molecules.
V82963	(S,R,S)-AHPC-C2-NH2 dihydrochloride	2341796-73-2	(S,R,S)-AHPC-C2-NH2 di-HCl contains the ligand VHL for E3 ubiquitin ligase and the PROTAC (PROteolysis TArgeting Chimera) linker.
V82999	(S,R,S)-AHPC-C3-NH2 hydrochloride (VH032-C3-NH2 hydrochloride)	2940858-65-9	(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 body and 1 linker, which may be utilized to prepare PROTAC molecules.
V82627	(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA)	2688842-02-4	(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VH032-based VHL ligand and 1 linker.
V82967	(S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2)	2306389-03-5	(S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker, which may be utilized to prepare PROTAC molecules.