E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V82468 | VH032-C4-NH-Boc | 2412055-00-4 | VH032-C4-NH-Boc is a Boc-modified VH032 , which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein. |
|
V82442 | VH032-C6-NH-Boc | 2306389-02-4 | VH032-C6-NH-Boc is a Boc-modified VH032, which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein. |
|
V82398 | VH032-NH-CO-CH2-NHBoc | 2010986-19-1 | VH032-NH-CO-CH2-NHBoc is a Boc-modified VH032 , which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein. |
|
V82437 | VH032-PEG2-NH-BOC | 2162120-75-2 | VH032-PEG2-NH-BOC is Boc-modified VH032 , which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein. |
|
V82424 | ZXH-4-137 | 2711006-74-3 | ZXH-4-137 is an effective and selective CRBN degrader (PROTAC). |
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