E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82492	Biotin-PEG9-amine	960132-48-3	Biotin-PEG9-amine is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82453	Bis-CH2-PEG2-acid	2250056-38-1	Bis-CH2-PEG2-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82501	Bis-isopropyl-PEG1	3944-35-2	Bis-isopropyl-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82400	Bis-PEG25-acid	2567200-14-8	Bis-PEG25-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82420	Bis-PEG7-t-butyl ester	2702251-39-4	Bis-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82401	Bis-propargyl-PEG10	1351373-48-2	Bis-propargyl-PEG10 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82355	BMS-1166-N-piperidine-CO-N-piperazine	2447066-14-8	BMS-1166-N-piperidine-CO-N-piperazine contains target protein PD-1/PD-L1 ligand and PROTAC (PROteolysis TArgeting Chimera) linker.
V82351	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride	2691796-83-3	BMS-1166-N-piperidine-CO-N-piperazine di-HCl contains target protein PD-1/PD-L1 ligand and PROTAC (PROteolysis TArgeting Chimera) linker.
V82352	BMS-1166-N-piperidine-COOH	2447066-00-2	BMS-1166-N-piperidine-COOH, based on BMS-1166, combines with E3 ligase ligand through a linker to form PROTAC PD-1/PD-L1 degrader-1 to degrade PD-1 /PD-L1.
V82443	Boc-bipiperidine-ethynylbenzoic acid	2308497-81-4	Boc-bipiperidine-ethynylbenzoic acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl/ether class, may be utilized to prepare the PROTAC molecule ARD-61.
V82399	Boc-NH-PEG8-C2-Br	2688072-12-8	Boc-NH-PEG8-C2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82519	Boc-NH-PPG2	1312905-31-9	Boc-NH-PPG2 is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V82363	Boc-NHCH2CH2-PEG1-azide	176220-30-7	Boc-NHCH2CH2-PEG1-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82520	Boc-PEG4-acid	2244684-38-4	Boc-PEG4-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82433	Boc-PEG5-methyl ester	1807530-04-6	Boc-PEG5-methyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82448	Boc-PEG8-Boc	1432970-18-7	Boc-PEG8-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82364	Boc-Pip-alkyne-Ph-COOH	2581824-70-4	Boc-Pip-alkyne-Ph-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker (PROTAC (PROteolysis TArgeting Chimera) linker), belonging to the alkyl/ether class.
V82369	Br-PEG4-THP	1803547-60-5	Br-PEG4-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82430	BRD4 ligand-Linker Conjugate 1	2154358-89-9	BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that may be utilized to prepare PROTAC.
V82502	Bromo-PEG3-THP	220568-33-2	Bromo-PEG3-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.