Target proteins are often proteins that may contribute significantly to the development of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy kinases (like MEK, KRAS, CDK, and Bcr/Abl), transcription factors (like p53, STAT, RAR, ER, and AR), epigenetic tools (like HDAC and BET bromodomain), and E3 ligases themselves (like MDM2).
Target proteins are often proteins that may contribute significantly to the progression of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy E3 ligases including MDM2, MEK, KRAS, CDK, and Bcr/Abl, transcription factors like p53, STAT, RAR, ER, and AR, epigenetic tools like HDAC, and BET bromodomain.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V77307 | Abemaciclib metabolite M18-d8 (LSN3106729-d8) | Abemaciclib metabolite M18-d8 is the deuterium labelled form of Abemaciclib metabolite M18. | |
|
V82617 | Amine-PEG3-Desthiobiotin | 2237234-71-6 | Amine-PEG3-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82612 | Amino-PEG23-amine | 2673284-93-8 | Amino-PEG23-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82604 | Azido-PEG8-TFP ester | 1818294-49-3 | Azido-PEG8-TFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V82609 | Benzyl-PEG4-MS | 477781-69-4 | Benzyl-PEG4-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82606 | Benzyl-PEG5-Ots | 129086-10-8 | Benzyl-PEG8-Ots is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category. |
|
V82610 | Bromo-PEG2-MS | 1935075-34-5 | Bromo-PEG2-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V51058 | CFT-1946 | PROTAC BRAFV600X degrader | |
|
V31695 | Dasatinib carbaldehyde | 2112837-79-1 | Dasatinib carbaldehyde, an analog of Dasatinib (BMS-354825;Sprycel) whichis an approved anticancer drug, binds to IAP ligand via a linker to form SNIPER . |
|
V82605 | DBCO-NHCO-PEG12-biotin | 2621391-31-7 | DBCO-NHCO-PEG12-biotin is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V51749 | Dimethyl-F-OICR-9429-COOH | 2407458-49-3 | Dimethyl-F-OICR-9429-COOH is a ligand for the target protein WD40 repeat domain protein 5 (WDR5) and can be used for the synthesis of PROTAC. |
|
V82613 | Dimethylamino-PEG3 | 2741-30-2 | Dimethylamino-PEG3 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V2592 | DUPA | 302941-52-2 | DUPA is a glutamate urea that serves as a targeting moiety in a bioactive molecule conjugate for the selective and targeted delivery of cytotoxic drugs to prostate cancer/tumor cells. |
|
V82614 | Ethyl-PEG4-alcohol | 5650-20-4 | Ethyl-PEG4-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V79579 | GID4 Ligand 1 | GID4 Ligand 1 (Compound 88) is a cell-permeable (penetrable) and selective GID4 binder (IC50=5.4 μM; Kd=5.6 μM) that binds to GID4 in cells (EC50=558 nM). | |
|
V80174 | GID4 Ligand 2 | GID4 Ligand 2 (Compound 67) is a selective GID4M binder (IC50=18.9 μM; Kd=17 μM). | |
|
V82603 | I-PEG6-OH | 136399-07-0 | I-PEG6-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82611 | Mal-PFP ester | 138194-55-5 | Mal-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders. |
|
V82601 | MS-PEG3-THP | 357204-84-3 | MS-PEG3-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82608 | NH2-C2-NH-Boc-d4 (PROTAC Linker 22-d4) | 509148-73-6 | NH2-C2-NH-Boc-d4 is the deuterated form of NH2-C2-NH-Boc. |
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