E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82347	DMAPT (Dimethylamino Parthenolide)	791595-09-0	DMAPT (Dimethylamino Parthenolide) is an analogue of Parthenolide (PTL) and an orally bioactive NF-κB inhibitor (antagonist) with an LD50 value of 1.7 μM against primary acute myeloid leukemia cells.
V82516	Dodecylheptaglycol	3055-97-8	Dodecylheptaglycol is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82440	DSPE-PEG2-mal	1915739-87-5	DSPE-PEG2-mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82345	dTAGV-1 TFA	2624313-15-9	dTAGV-1 TFA is a potent and specific degrader of mutant FKBP12F36V fusion protein.
V31357	E3 ligase Ligand 17 hydrochloride	2305369-00-8	E3 ligase Ligand 17 hydrochloride is a ligand for E3 ubiquitin ligase.
V82494	E3 ligase Ligand 18	2241669-88-3	E3 ligase Ligand 18 is an E3 ubiquitin ligase ligand.
V31729	E3 Ligase Ligand-Linker Conjugates 1	2097938-44-6	E3 Ligase Ligand-Linker Conjugate 1 incorporates a ligand for the E3 ubiquitin ligase, and a PROTAC linker, which bring together target protein and ubiquitinating machinery.
V31992	E3 ligase Ligand-Linker Conjugates 14	1957236-21-3	E3 ligase Ligand-Linker Conjugates 14 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
V32227	E3 ligase Ligand-Linker Conjugates 19 TFA	1799711-25-3	E3 ligase Ligand-Linker Conjugates 19 TFA is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
V32177	E3 Ligase Ligand-Linker Conjugates 2	1818885-63-0	E3 Ligase Ligand-Linker Conjugates 2,(Pomalidomide-PEG4-Ph-NH2, Cereblon Ligand-Linker Conjugates 9)incorporates a ligand for the E3 ubiquitin ligase, and a PROTAC linker, which bring together target protein and ubiquitinating machinery.
V32005	E3 Ligase Ligand-Linker Conjugates 20 TFA	1950635-16-1	E3 Ligase Ligand-Linker Conjugates 20 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
V31913	E3 Ligase Ligand-Linker Conjugates 52 (TFA)	2022182-58-5	E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) incorporates a CRBN ligand for the E3 ubiquitin ligase, and a PROTAC linker.
V82503	E3 ubiquitin ligase binder-1	2446913-99-9	E3 ubiquitin ligase binder-1 (compound 11) is a potent E3 ubiquitin ligase binder.
V79294	EN219-O-C4-NH2 TFA		EN219-O-C4-NH2 TFA contains ligands and linkers for recruiting E3 ubiquitin ligases.
V82348	endo-BCN-PEG4-Val-Cit-PAB-MMAE	2762519-08-2	endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC (Antibody-drug conjugate) linker containing 4 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V82499	Fmoc-NH-PEG25-CH2CH2COOH	1257223-69-0	Fmoc-NH-PEG25-CH2CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82417	Fmoc-PEG3-alcohol	560088-66-6	Fmoc-PEG3-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V33147	Fmoc-Val-Cit-PAB-MMAE	1350456-56-2	Fmoc-Val-Cit-PAB-MMAE is a novel drug-linker conjugate used for ADC.
V82508	Folate-PEG1-mal	2743004-48-8	Folate-PEG1-mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82340	Glucose oxidase	9001-37-0	Glucose oxidase may be used in the food and beverage industry as a preservative and stabilizer and is usually derived from the fungus Aspergillus niger.