| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| Other Sizes |
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| ln Vitro |
β-Chloro-L-alanine inhibits threonine deaminase, branched-chain amino acid transaminase (transaminase B), L-aspartate-β-decarboxylase, alanine racemase, and perhaps O-acetylserine Hydrogen sulfide enzyme. β-Chloro-L-alanine reversibly inhibits Escherichia coli K-12 alanine-valine aminotransferase and transaminase C. This inhibition, combined with the inhibition of transaminase B, explains the necessity of E. coli for isoleucine plus valine in the presence of β-chloro-L-alanine. Salmonella enterica serovar Typhimurium LT2 will grow in the presence of BCA if isoleucine and valine are added to the culture media, and it is postulated that the growth requirement is due to inhibition of aminotransferase B [1].
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|---|---|
| References |
[1]. β-Chloro-L-alanine can inhibits threonine deaminase, the branched-chain amino acid transaminase (transaminase B), L-aspartate-pdecarboxylase, alanine racemase and probably O-acetylserine sulfhydrylase. β-Chloro-L-alanine reversibly inhibits the Escheri
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| Additional Infomation |
3-chloro-L-alanine is a 3-chloroalanine that has R configutation at the chiral centre. It is a L-alanine derivative and a 3-chloroalanine. It is an enantiomer of a 3-chloro-D-alanine. It is a tautomer of a 3-chloro-L-alanine zwitterion.
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| Molecular Formula |
C3H6CLNO2
|
|---|---|
| Molecular Weight |
123.5382
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| Exact Mass |
123.008
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| CAS # |
2731-73-9
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| Related CAS # |
3-Chloro-L-alanine Hydrochloride;51887-89-9
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| PubChem CID |
439772
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
243.6±30.0 °C at 760 mmHg
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| Melting Point |
156 °C
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| Flash Point |
101.1±24.6 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.499
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| LogP |
-0.13
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
7
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| Complexity |
75.3
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| Defined Atom Stereocenter Count |
1
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| SMILES |
ClC([H])([H])[C@@]([H])(C(=O)O[H])N([H])[H]
|
| InChi Key |
ASBJGPTTYPEMLP-REOHCLBHSA-N
|
| InChi Code |
InChI=1S/C3H6ClNO2/c4-1-2(5)3(6)7/h2H,1,5H2,(H,6,7)/t2-/m0/s1
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| Chemical Name |
(2R)-2-amino-3-chloropropanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 30 mg/mL (~242.84 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (404.73 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.0945 mL | 40.4727 mL | 80.9454 mL | |
| 5 mM | 1.6189 mL | 8.0945 mL | 16.1891 mL | |
| 10 mM | 0.8095 mL | 4.0473 mL | 8.0945 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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