| Size | Price | Stock | Qty |
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| 500mg |
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| Other Sizes |
| Targets |
α-L-Rhamnose monohydrate is a component of plant cell wall polysaccharides and bacterial polysaccharides. It plays important roles in plant cell wall structure and bacterial pathogenicity. The compound is a monosaccharide used in various applications including medical research, environmental research, and industrial research. Its mechanism of action is related to its role as a structural sugar in polysaccharides.
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| ln Vitro |
In vitro, α-L-Rhamnose monohydrate is used as a sugar in biochemical research. It is a component of plant cell wall pectic polysaccharides. The compound is used in studies of plant cell wall structure and bacterial polysaccharides. Its role as a sugar substrate has been characterized in various in vitro systems. Further in vitro studies are needed to fully characterize its biological activity.
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| ln Vivo |
In vivo, α-L-Rhamnose monohydrate is a component of plant cell wall pectic polysaccharides and bacterial polysaccharides. It plays important roles in plant cell wall structure and bacterial pathogenicity. The compound is used in medical, environmental, and industrial research. Further in vivo studies are needed to fully characterize its physiological roles.
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| Enzyme Assay |
In vitro enzyme assays for α-L-Rhamnose monohydrate involve measuring its role as a substrate for glycosidases and other carbohydrate-active enzymes. Enzyme activity is assessed by monitoring the hydrolysis of rhamnose-containing substrates. The compound is used in studies of plant cell wall degradation and bacterial polysaccharide metabolism. Assays are performed in appropriate buffer systems with positive controls.
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| Cell Assay |
In vitro cell-based assays for α-L-Rhamnose monohydrate are conducted in plant cells and bacterial cultures. Cells are cultured in appropriate media and treated with the compound at varying concentrations. Cell wall metabolism and polysaccharide synthesis are assessed. Bacterial pathogenicity is assessed in bacterial cultures. Cell viability is assessed by standard assays. Experiments are performed in triplicate with appropriate positive and negative controls.
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| Animal Protocol |
α-L-Rhamnose monohydrate in vivo studies are conducted in plant models for cell wall research and in animal models for pathogenicity studies. Plants are treated with the compound and cell wall structure is analyzed. For bacterial pathogenicity studies, animals are infected with bacteria and pathogenicity is assessed. Animals are monitored for clinical signs. Tissues and blood samples are collected for histopathological and biochemical analysis. Studies are conducted in accordance with institutional animal care guidelines.
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| ADME/Pharmacokinetics |
α-L-Rhamnose monohydrate (MW 182.17 g/mol, C6H14O6) is a naturally occurring monosaccharide. It is a methyl five-carbon sugar (6-deoxyhexose). The compound is soluble in water. It is stable under recommended storage conditions. α-L-Rhamnose monohydrate is used in medical, environmental, and industrial research. Pharmacokinetic parameters such as absorption, distribution, metabolism, and excretion would be determined in species-specific studies.
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| Toxicity/Toxicokinetics |
α-L-Rhamnose monohydrate is generally well-tolerated as a naturally occurring sugar. The compound is a component of plant and bacterial polysaccharides. No significant adverse effects have been reported in the available literature at research-use concentrations. The compound is intended for research use only. Standard laboratory safety practices should be employed when handling this compound. Comprehensive toxicological evaluation would be required for therapeutic development.
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| References | |
| Additional Infomation |
α-L-Rhamnose monohydrate is a naturally occurring sugar and a component of plant cell wall pectic polysaccharides rhamnogalacturonan I and II. It is also a component of bacterial polysaccharides and plays important roles in pathogenicity. The compound is used in medical, environmental, and industrial research. Its molecular formula is C6H14O6 with a molecular weight of 182.17 g/mol.All applications are limited to non-human research use.
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| Molecular Formula |
C6H14O6
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| Molecular Weight |
182.1718
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| Exact Mass |
182.079
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| CAS # |
6155-35-7
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| PubChem CID |
22856332
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| Appearance |
White to off-white solid powder
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| Boiling Point |
323.9ºC at 760 mmHg
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| Melting Point |
90-95ºC
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| Flash Point |
149.7ºC
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
12
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| Complexity |
139
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| Defined Atom Stereocenter Count |
5
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| SMILES |
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O)O)O)O.O
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| InChi Key |
BNRKZHXOBMEUGK-NRBMBCGPSA-N
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| InChi Code |
InChI=1S/C6H12O5.H2O/c1-2-3(7)4(8)5(9)6(10)11-2;/h2-10H,1H3;1H2/t2-,3-,4+,5+,6+;/m0./s1
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| Chemical Name |
(2R,3R,4R,5R,6S)-6-methyloxane-2,3,4,5-tetrol;hydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~548.94 mM)
DMSO : ~100 mg/mL (~548.94 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (13.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (548.94 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL | |
| 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL | |
| 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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