ZM 39923 HCl

Alias:
Cat No.:V0329 Purity: ≥98%
ZM 39923 HCl, the hydrochloride salt of ZM-39923,is a novel and potent inhibitor of Janus kinase-JAK1/3 with potential anti-inflammatory activity.
ZM 39923 HCl Chemical Structure CAS No.: 1021868-92-7
Product category: JAK
This product is for research use only, not for human use. We do not sell to patients.
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Other Forms of ZM 39923 HCl:

  • ZM-39923
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

ZM 39923 HCl, the hydrochloride salt of ZM-39923, is a novel and potent inhibitor of Janus kinase-JAK1/3 with potential anti-inflammatory activity. It inhibits JAK1/3 with pIC50s of 4.4/7.1, and shows little/no activity against JAK2 and modestly potency to EGFR; also found to be sensitive to transglutaminase.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
ZM39923 hydrochloride has a pIC50 of 7.1, making it a JAK3 inhibitor. ZM39923 (Compound 7) inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0) and EGF-R and JAK1 (pIC50, 5.6, and 4.4, respectively) with a modest inhibitory effect[1]. ZM39923 acts directly on pure TGM2 to inhibit the Ca2+ activated form of TGM2, and it potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM[2]. ZM39923 inhibits JAK3 phosphorylation brought on by CCL19; this action is comparable to that of an anti-CCR7 antibody. ZM39923 also dramatically reduces PCI-37B cell migration and invasion and prevents the CCL19-induced wound closure rate[3].
ln Vivo

Animal Protocol


References
[1]. Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9.
[2]. Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78.
[3]. Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C23H25NO.HCL
Molecular Weight
367.91
CAS #
1021868-92-7
SMILES
Cl[H].O=C(C1C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C2C=1[H])C([H])([H])C([H])([H])N(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
Synonyms

Synonym:ZM 39923; ZM-39923; ZM39923 HCl;ZM39923;ZM 39923 Hydrochloride;

Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 30 mg/mL (81.5 mM)
Water:<1 mg/mL
Ethanol:8 mg/mL (21.7 mM)
Solubility (In Vivo)

Chemical Name:3-[Benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one hydrochloride

InChi Key:NJTUORMLOPXPBY-UHFFFAOYSA-N

InChi Code:InChI=1S/C23H25NO.ClH/c1-18(2)24(17-19-8-4-3-5-9-19)15-14-23(25)22-13-12-20-10-6-7-11-21(20)16-22;/h3-13,16,18H,14-15,17H2,1-2H3;1H

SMILES Code:O=C(C1=CC=C2C=CC=CC2=C1)CCN(CC3=CC=CC=C3)C(C)C.[H]Cl

 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.7181 mL 13.5903 mL 27.1806 mL
5 mM 0.5436 mL 2.7181 mL 5.4361 mL
10 mM 0.2718 mL 1.3590 mL 2.7181 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Biological Data
  • ZM 39923 HCl

    Ca+2-dependent Inhibition of TGase/TGM2 by chemical inhibitors.Chem Biol.2008 Sep 22;15(9):969-78.

  • ZM 39923 HCl

    Fluorescent GTP Binding Assay.Chem Biol.2008 Sep 22;15(9):969-78.

  • ZM 39923 HCl

    Effects of chemical inhibitors in rescuing Drosophila in HD model of neurodegeneration.Chem Biol.2008 Sep 22;15(9):969-78.

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