| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
White mineral oil does not target specific biological receptors. It is an inert vehicle and lubricant. It resists moisture, stretches, softens, smoothens, and lubricates. It does not support the growth of pathogenic bacteria.
|
|---|---|
| ln Vitro |
White mineral oil is not a bioactive compound in typical drug activity assays. It is used as an inert excipient, a lubricant, a plasticizer, and a vehicle for drug delivery in topical and oral formulations. It is also used to prepare Nujol mulls for IR spectroscopy.
|
| ln Vivo |
White mineral oil is not a pharmacologically active compound. In vivo, it functions as an inert vehicle or lubricant. Orally administered mineral oil is not absorbed from the gastrointestinal tract and is excreted unchanged in the feces. Topical application provides an occlusive barrier that reduces transepidermal water loss.
|
| Enzyme Assay |
Not applicable. For Nujol mull preparation: The solid sample (1-5 mg) is ground to a fine powder in an agate mortar. 1-2 drops of white mineral oil are added, and the mixture is ground to a smooth paste. The mull is pressed between two salt plates (NaCl or KBr) and analyzed by IR spectroscopy.
|
| Cell Assay |
White mineral oil is not used in live-cell assays as it is an inert vehicle. For cytotoxicity studies in drug delivery research, cells are cultured and treated with formulations containing varying concentrations of mineral oil (0.1-10% v/v) for 24-72 hours. Cell viability is assessed by MTT or CellTiter-Glo to evaluate the safety of mineral oil as an excipient.
|
| Animal Protocol |
White mineral oil is administered to animals (e.g., rats, mice) as an inert vehicle for poorly soluble drugs, typically by oral gavage (up to 5 mL/kg) or topical application. Blood samples are collected for pharmacokinetic analysis of the dissolved drug. Mineral oil itself is not absorbed and serves as a control in vehicle toxicity studies.
|
| ADME/Pharmacokinetics |
Mineral oil is not absorbed from the gastrointestinal tract and is excreted in feces. Orally administered mineral oil (1-5 mL/kg in animals) has a laxative effect and may interfere with absorption of fat-soluble vitamins. Storage at room temperature; ambient shipping. Density: 0.877. Flash point: 220degC.
|
| Toxicity/Toxicokinetics |
Mineral oil is generally regarded as safe (GRAS) for use as a food additive (E905a) and in topical pharmaceutical formulations at levels up to 100%. Chronic inhalation of mineral oil mist may cause lipoid pneumonia. Aspiration into the lungs can cause serious chemical pneumonitis. Standard handling precautions: avoid inhalation of mists, use PPE.
|
| Additional Infomation |
White mineral oil is an approved pharmaceutical excipient (USP-NF monograph) and food additive. It is used in personal care products, cosmetics, pharmaceuticals (topical creams/ointments, oral solutions), and food processing. It is also known as Liquid Paraffin and Petrolatum Liquid. Molecular formula: variable, typically hydrocarbon mixtures.
|
| Molecular Formula |
C16H10N2NA2O7S2
|
|---|---|
| Molecular Weight |
452.369343280792
|
| CAS # |
8042-47-5
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
0.877
|
| Flash Point |
220 ºC
|
| Index of Refraction |
1.476-1.483
|
| SMILES |
S(C1C=C(C=C2C=CC(=C(C2=1)/N=N/C1C=CC=CC=1)O)S(=O)(=O)[O-])(=O)(=O)[O-].[Na+].[Na+]
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (Infinity mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2106 mL | 11.0529 mL | 22.1058 mL | |
| 5 mM | 0.4421 mL | 2.2106 mL | 4.4212 mL | |
| 10 mM | 0.2211 mL | 1.1053 mL | 2.2106 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
