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Purity: ≥98%
Valrocemide, formerly known as TV-1901, is an antiepileptic drug (AED). Valrocemide has a broad spectrum of anticonvulsant activity and promising potential as a new AED. Valrocemide is an anticonvulsant agent under development by Teva and Acorda as a potential therapeutic for the treatment of epilepsy.
| ln Vivo |
The study found that mice were completely protected against 6 Hz "psychomotor" seizures as well as seizures caused by pentylenetetrazole, picrotoxin, and bicuculline, with median effective dosage (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively. In Frings audiogenic epilepsy-susceptible mice, valrocemide likewise effectively prevents sound-induced seizures (ED50, 52 mg/kg). 332 mg/kg was the median hazardous dosage in mice. Vasotecime was active in the MES test after oral administration to rats, with an ED50 of 73 mg/kg and a median neurotoxic dosage of 1,000 mg/kg. In Sprague-Dawley rats with hippocampally ignited hippocampus, an intraperitoneal dose of 300 mg/kg prolosemide avoided generalized seizures and markedly reduced the afterdischarge period. Rats with corneal ignition were similarly completely protected against focal seizures (ED50, 161 mg/kg) by valrocemide [1].
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| References |
[1]. Isoherranen N, et al. Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. Epilepsia. 2001 Jul;42(7):831-6
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| Molecular Formula |
C10H20N2O2
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|---|---|
| Molecular Weight |
200.282
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| Exact Mass |
200.1525
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| CAS # |
92262-58-3
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| Related CAS # |
92262-58-3
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| SMILES |
CCCC(CCC)C(NCC(N)=O)=O
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| InChi Key |
RALGCAOVRLYSMA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H20N2O2/c1-3-5-8(6-4-2)10(14)12-7-9(11)13/h8H,3-7H2,1-2H3,(H2,11,13)(H,12,14)
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| Chemical Name |
N-(2-amino-2-oxoethyl)-2-propylpentanamide
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| Synonyms |
Valrocemide TV-1901 TV 1901 TV1901 SPD-493 TVP-1901 SPD493 TVP1901 SPD 493 TVP 1901. N-Valproyl glycinamide.
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~499.30 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.75 mg/mL (13.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.75 mg/mL (13.73 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.75 mg/mL (13.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9930 mL | 24.9650 mL | 49.9301 mL | |
| 5 mM | 0.9986 mL | 4.9930 mL | 9.9860 mL | |
| 10 mM | 0.4993 mL | 2.4965 mL | 4.9930 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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