My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()

    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V0086
    CAS #: 1184136-10-4 Purity ≥98%

    Description: UNC-926 is a potent and selective inhibitor of the L3MBTL1 (Lethal(3)malignant brain tumor-like protein) domain (Kd = 3.9 μM), which is a methyl-lysine (Kme) reader domain. UNC-926 acts by binding to the MBT domain of the L3MBTL1 protein. In a peptide pull down assay, UNC-926 was found to be able to selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction.

    References: Med. Chem. Commun., 2012, 3, 45-51;  2016 Sep 15;26(18):4436-4440. 

    Related CAS: 1782573-49-2 (HCl); 1581296-53-8 (TFA)  

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW) 337.25
    Formula C16H21BrN2O
    CAS No. 1184136-10-4 (free base); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 67 mg/mL (198.7 mM)
    Water: < 1mg/mL
    Ethanol: 2 mg/mL (5.9 mM)
    Chemical Name (3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone
    Synonyms UNC926 free base; UNC 926 free base; UNC-926 free base; UNC-926; UNC926; UNC 926

    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      • V1
      • C2
      • V2
    In Vitro

    In vitro activity: UNC-926 is an inhibitor of the L3MBTL1 (Lethal(3)malignant brain tumor-like protein) domain. It binds to the MBT domain of the L3MBTL1 protein with a Kd value of 3.9 μM. The interaction between methyl-lysine binding proteins and methylated histones plays a crucial role in the regulation of gene expression. UNC-926 was demonstrated to successfully inhibit the recognition of H4K20me1 by L3MBTL1 in the context of an affinity pull down assay. Mounting evidence suggests that epigenetic alterations relate to various human diseases including inflammation, brain disorders, metabolic diseases, and cancer.1, 2, 3 One such epigenetic modification is histone lysine methylation. 

    Kinase Assay: UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1

    In Vivo
    Animal model
    Formulation & Dosage
    References Med. Chem. Commun., 2012, 3, 45-51;  2016 Sep 15;26(18):4436-4440. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


    Compound 2 selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. Med. Chem. Commun., 2012, 3, 45-51


    Structures of L3MBTL1/L3MBTL3 inhibitors.  2016 Sep 15;26(18):4436-4440.


    Compound 13 binds SETD8 with an IC50 of 39 ± 11 μM.  2016 Sep 15;26(18):4436-4440.


      Home Prev Next Last page / pices


      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      Do you confirm the receipt?