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    Ulipristal (CDB-2914)
    Ulipristal (CDB-2914)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1752
    CAS #: 159811-51-5 Purity ≥98%

    Description: Ulipristal (CDB-2914; HRP2000, VA2914, RTI 3021-012, RU 44675, EllaOne, Ella, Esmya) is a potent and selective SPRM (selective progesterone receptor modulator) used for emergency contraception after an unprotected intercourse or contraceptive failure. Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to the glucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors. Ulipristal acetate dose dependently suppressed progesterone-induced acrosome reaction and hyperactivation in human spermatozoa.

    References: J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88; Clin Ther. 2012 Jan;34(1):24-36. 

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    Molecular Weight (MW)433.58 
    FormulaC28H35NO3 
    CAS No.159811-51-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (191.4 mM) 
    Water: <1 mg/mL
    Ethanol: 14 mg/mL (32.3 mM) 
    Other info

    Chemical Name: (8S,11R,13S,14S,17R)-17-acetyl-11-(4-(dimethylamino)phenyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

    InChi Key: OOLLAFOLCSJHRE-ZHAKMVSLSA-N

    InChi Code: InChI=1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1

    SMILES Code: CC([[email protected]@]1(OC(C)=O)CC[[email protected]@]2([H])[[email protected]]3([H])CCC4=CC(CCC4=C3[[email protected]@H](C5=CC=C(N(C)C)C=C5)C[[email protected]]12C)=O)=O           

    SynonymsCDB-2914; HRP2000, VA2914, RTI 3021-012, RU 44675, CDB2914, HRP 2000, VA-2914, CDB 2914, CDB-2914, CDB 2914, CDB2914, HRP-2000,  VA 2914, Ulipristal acetate, EllaOne, Ella, Esmya


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    In Vitro

    In vitro activity: Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to theglucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.

    In VivoBased on clinical trials, ulipristal acetate seems to be a reasonably tolerable and effective method of emergency contraception when used within 120 hours of intercourse. Ulipristal acetate is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, ulipristal acetate may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for emergency contraception. 
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    References

    J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88; Clin Ther. 2012 Jan;34(1):24-36.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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