Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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ln Vitro |
AFLPHRLF, or human tyrosinase(206–214), can be utilized to produce peptide vaccines for HLA-A24+ melanoma and melanoma-specific T lymphocytes for adoptive immunotherapy [1].
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ln Vivo |
Tyrosinase (206-214) was delivered intranasally (45 µL; once weekly for three weeks) to HLA-A24 transgenic (A24Tg) mice. Tyrosinase (206-214) indicates increase of mouse CD3+ and CD8+ lymphocytes around bronchioles. All A24Tg immunized with tyrosinase (206-214) perished following lethal A/HK483 infection [2].
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References |
[1]. X Kang, et al. Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes. J Immunol. 1995 Aug 1;155(3):1343-8.
[2]. Toru Ichihashi, et al. Cross-protective peptide vaccine against influenza A viruses developed in HLA-A*2402 human immunity model. PLoS One. 2011;6(9):e24626. |
Molecular Formula |
C61H83N15O10
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Molecular Weight |
1186.40623307228
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CAS # |
166188-11-0
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SMILES |
C(O)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1N=CNC=1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](C)N
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~125 mg/mL (~105.36 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.8429 mL | 4.2144 mL | 8.4288 mL | |
5 mM | 0.1686 mL | 0.8429 mL | 1.6858 mL | |
10 mM | 0.0843 mL | 0.4214 mL | 0.8429 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.