| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 10mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| Other Sizes |
|
| ln Vitro |
In lipopolysaccharide-stimulated RAW 264.7 cells and the peritoneum, tussilagone suppresses the expression of inflammatory mediators such as nitric oxide and prostaglandin E2, as well as inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and high mobility group box 1 (HMGB1). Phagocytosis. Additionally, tussilagone lessens the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase, which are involved in the activation of several inflammatory mediators in activated macrophages [1].
|
|---|---|
| ln Vivo |
In mice with CLP-activated sepsis, tussilagone treatment (1 mg/kg and 10 mg/kg) decreased lung damage and mortality. An injection of tussilagone can reduce the increased production of TNF-α and cyclooxygenase (COX)-2 in the alveolar macrophages of septic mice [2].
|
| References |
|
| Additional Infomation |
Unii-95N0gbb2SX has been reported in Parasenecio petasitoides and Tussilago farfara with data available.
See also: Tussilago farfara flower (part of); Tussilago farfara leaf (part of). |
| Molecular Formula |
C23H34O5
|
|---|---|
| Molecular Weight |
390.52
|
| Exact Mass |
390.24
|
| CAS # |
104012-37-5
|
| PubChem CID |
13919185
|
| Appearance |
White to off-white solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
471.3±35.0 °C at 760 mmHg
|
| Flash Point |
200.7±26.0 °C
|
| Vapour Pressure |
0.0±1.2 mmHg at 25°C
|
| Index of Refraction |
1.502
|
| LogP |
5.03
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
8
|
| Heavy Atom Count |
28
|
| Complexity |
675
|
| Defined Atom Stereocenter Count |
6
|
| SMILES |
CC/C(=C/C(=O)O[C@@H]1C[C@H]([C@H]2[C@H](C1=C)CC(=O)[C@@H]2[C@@H](C)OC(=O)C)C(C)C)/C
|
| InChi Key |
CFUPNMDNSQIWBB-UUVDBSHOSA-N
|
| InChi Code |
InChI=1S/C23H34O5/c1-8-13(4)9-21(26)28-20-11-17(12(2)3)23-18(14(20)5)10-19(25)22(23)15(6)27-16(7)24/h9,12,15,17-18,20,22-23H,5,8,10-11H2,1-4,6-7H3/b13-9+/t15-,17+,18+,20-,22+,23+/m1/s1
|
| Chemical Name |
[(1S,3aR,5R,7S,7aS)-1-[(1R)-1-acetyloxyethyl]-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl] (E)-3-methylpent-2-enoate
|
| Synonyms |
L 652469; L-652469; Tussilagone
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~62.5 mg/mL (~160.05 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (16.00 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5607 mL | 12.8034 mL | 25.6069 mL | |
| 5 mM | 0.5121 mL | 2.5607 mL | 5.1214 mL | |
| 10 mM | 0.2561 mL | 1.2803 mL | 2.5607 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
