| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
At 50 and 100 μM, triclosan (1-100 μM; 24 hours) decreases cell viability in a dose- and time-dependent manner. A 50 μM dose of triclosan dramatically raises the protein Bax and cleaved caspase 3, while lowering Bcl-2[2]. Phosphorylated p38 and JNK proteins are more highly expressed when exposed to 50 μM triclosan for 1-3 hours [2]. In cultured NSCs, triclosan (10–50 μM; 3 hours) at 50 μM decreases GSH activity and raises ROS generation to around 40% [2].
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|---|---|
| ln Vivo |
Triclosan (5, 50, and 500 mg/kg; oral gavage, five days a week for four weeks) induced the production of IL-4, IL-13, and anti-Der f IgE [3].
|
| Cell Assay |
Cell Viability Assay[2]
Cell Types: Neural stem wells Tested Concentrations: 1, 10, 20, 30, 50 and 100 μM Incubation Duration: 24 h Experimental Results: Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Western Blot Analysis[2] Cell Types: Neural stem wells Tested Concentrations: 50 μM Incubation Duration: 1, 3 h Experimental Results: Did not affect the expressions of MAPK signaling proteins per se. Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins . |
| Animal Protocol |
Animal/Disease Models: Wild type BALB/cJ mice[3]
Doses: 5, 50, 500 mg/kg Route of Administration: po (oral gavage), five days a week for a total of four weeks Experimental Results: Caused an increase in the production of anti-dermatophagoides farinae (Der f) IgE, IL‐4, and IL‐13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen‐exposed wild type mice. |
| References |
[1]. Weatherly LM, et al. Triclosan exposure, transformation, and human health effects. J Toxicol Environ Health B Crit Rev. 2017;20(8):447-469.
[2]. Ley C, et al. Triclosan and triclocarban exposure and thyroid function during pregnancy-A randomized intervention. Reprod Toxicol. 2017 Dec;74:143-149. |
| Molecular Formula |
C12H7CL3O2
|
|---|---|
| Molecular Weight |
289.54178071022
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| CAS # |
3380-34-5
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| Related CAS # |
Triclosan-d3;1020719-98-5
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| SMILES |
OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~345.38 mM)
H2O : ~1 mg/mL (~3.45 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.63 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.63 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4538 mL | 17.2688 mL | 34.5375 mL | |
| 5 mM | 0.6908 mL | 3.4538 mL | 6.9075 mL | |
| 10 mM | 0.3454 mL | 1.7269 mL | 3.4538 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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