| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
| Targets |
Tricarballylic acid does not have a specific pharmacological target. It is a tricarboxylic acid used primarily as a chemical building block and ligand. The compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives, which are carboxylic acids containing exactly three carboxyl groups. It is used as an alternative to DMDHEU (formaldehyde-releasing cross-linking agent) in industrial applications. In biological systems, tricarballylic acid may interact with metal ions and serve as a chelator or ligand. Its role as a small biomimetic ligand suggests potential applications in coordination chemistry and materials science rather than pharmacology.
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| ln Vitro |
In vitro, Tricarballylic acid is used as a small biomimetic ligand and building block in the synthesis of metal-organic frameworks. It is a tricarboxylic acid with three carboxyl groups. The compound is also used as an alternative to DMDHEU (formaldehyde-releasing cross-linking agent). Its in vitro activity is primarily related to its chemical properties as a polycarboxylic acid rather than specific biological effects. The compound may be used in biochemical studies as a metal chelator or as a reference compound for tricarboxylic acid metabolism. It is a white to almost white crystalline powder with good solubility in water and methanol.
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| ln Vivo |
In vivo, Tricarballylic acid is not used as a therapeutic agent. It is primarily an industrial chemical and research reagent used as a building block in the synthesis of metal-organic frameworks and as an alternative to formaldehyde-releasing cross-linking agents. The compound is also known as 1,2,3-propanetricarboxylic acid. In biological systems, it may be metabolized through tricarboxylic acid pathways. However, detailed in vivo pharmacokinetic and toxicological data for Tricarballylic acid are not extensively reported. The compound is intended for research and industrial use only.
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| Enzyme Assay |
In vitro enzyme/receptor binding (non-cellular) assays are not applicable to Tricarballylic acid, as it is primarily a chemical building block and ligand rather than a bioactive compound. However, the compound may be used as a ligand in coordination chemistry studies. Metal-binding assays can be performed by incubating Tricarballylic acid with metal ions such as Fe³⁺, Cu²⁺, or Zn²⁺ in buffer solutions, followed by measurement of complex formation using spectroscopic methods (UV-Vis, fluorescence) or potentiometric titration. The compound's ability to form metal-organic frameworks is of interest in materials science. These assays help characterize the compound's coordination chemistry and metal-binding properties.
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| Cell Assay |
In vitro cellular experiments with Tricarballylic acid are not typically performed for pharmacological evaluation, as the compound is primarily a chemical building block and ligand. However, cellular assays may be conducted to assess its cytotoxicity or effects on cellular metabolism. Cell lines such as hepatocytes or fibroblasts may be treated with varying concentrations of Tricarballylic acid, and cell viability is assessed using MTT or CellTiter-Glo assays. The compound's effects on cellular metal homeostasis or tricarboxylic acid metabolism may also be investigated. The compound is a white to almost white crystalline powder and is soluble in water and methanol. Cells are maintained at 37°C in 5% CO₂ with appropriate media supplements.
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| Animal Protocol |
In vivo animal studies with Tricarballylic acid are not typically performed for therapeutic development, as the compound is primarily an industrial chemical and research reagent. However, toxicological studies may be conducted to assess its safety for industrial use. Rodents or other animals are administered Tricarballylic acid via oral or other routes at various doses. Parameters assessed include body weight, organ weights, histopathological examination, and clinical signs of toxicity. The compound is also used as an alternative to formaldehyde-releasing cross-linking agents, and its safety profile may be relevant to industrial applications. Further toxicological studies may be required for regulatory approval.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Tricarballylic acid are not extensively characterized. The compound has molecular formula C₆H₈O₆ and molecular weight 176.12 g/mol. It appears as a white to almost white crystalline powder with a melting point of 156-161°C. Solubility: soluble in water (500 mg/mL at 18°C), methanol, and slightly soluble in ether. Purity: ≥97%. As a small polar molecule with three carboxyl groups, it is expected to have limited membrane permeability and is primarily excreted in urine. Storage: follow manufacturer's guidelines.
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| Toxicity/Toxicokinetics |
Toxicological information for Tricarballylic acid indicates that it has a GHS signal word of "Warning". The compound appears as a white to almost white crystalline powder. Standard safety precautions for handling chemicals apply, including use of personal protective equipment (gloves, safety goggles, lab coat) and working in a well-ventilated area. The compound may cause skin, eye, or respiratory irritation at high concentrations. Purity: ≥97%. Storage: follow manufacturer's guidelines.
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| References | |
| Additional Infomation |
Propyl tricarboxylate is a tricarboxylic acid, which is the product of glutaric acid where one β-hydrogen atom is replaced by a carboxyl group. It is the conjugate acid of propyl tricarboxylate.
Tricarballylic acid (CAS 99-14-9) is a tricarboxylic acid with molecular formula C₆H₈O₆ and molecular weight 176.12 g/mol. It appears as a white to almost white crystalline powder with a melting point of 156-161°C. The compound is soluble in water (500 mg/mL at 18°C) and methanol, and slightly soluble in ether. Tricarballylic acid is also known as 1,2,3-propanetricarboxylic acid. It is used as a building block in the synthesis of metal-organic frameworks and as an alternative to formaldehyde-releasing cross-linking agents. Purity: ≥97%. |
| Molecular Formula |
C6H8O6
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|---|---|
| Molecular Weight |
176.1241
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| Exact Mass |
176.032
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| CAS # |
99-14-9
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| PubChem CID |
14925
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| Appearance |
White to off-white solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
266.4±20.0 °C at 760 mmHg
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| Melting Point |
156-161 °C(lit.)
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| Flash Point |
129.2±18.3 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.529
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| LogP |
-1.33
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
12
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| Complexity |
192
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
KQTIIICEAUMSDG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H8O6/c7-4(8)1-3(6(11)12)2-5(9)10/h3H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
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| Chemical Name |
propane-1,2,3-tricarboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~1419.49 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (11.81 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (11.81 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (11.81 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.6779 mL | 28.3897 mL | 56.7795 mL | |
| 5 mM | 1.1356 mL | 5.6779 mL | 11.3559 mL | |
| 10 mM | 0.5678 mL | 2.8390 mL | 5.6779 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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