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    Trelagliptin (SYR472; Zafatek)
    Trelagliptin (SYR472; Zafatek)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0746
    CAS #: 865759-25-7Purity ≥98%

    Description: Trelagliptin (formerly also known as SYR-472; trade name Zafatek) is a potent, highly selective, long-acting DPP-4 (dipeptidyl peptidase-4) inhibitor with potential anti-hyperglycemic activity. It was under development by Takeda and approved in Japan for the treatment of type 2 diabetes (T2D). Unlike other approved drugs of the same class that are usually administered once daily, trelagliptin can be given once weekly, which is an advantage. 

    References: Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32.

    Related CAS #:  865759-25-7 (free base)  1029877-94-8 (succinate)                                                                              

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    Molecular Weight (MW)357.38
    FormulaC18H20FN5O2
    CAS No.865759-25-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 71 mg/mL (198.7 mM) 
    Water:<1 mg/mL
    Ethanol: 3 mg/mL warmed (8.4 mM)
    Solubility (In vivo)

    Chemical Name: (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile.

    InChi Key: IWYJYHUNXVAVAA-OAHLLOKOSA-N

    InChi Code: InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1

    SMILES Code: N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[[email protected]](N)CCC3)=CC2=O           

    SynonymsSYR 472; Trelagliptin; SYR-472; SYR472; trade name: Zafatek.


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    In Vitro

    In vitro activity:  Trelagliptin (also known as SYR-472) is a potent, highly selective, long-acting DPP-4 (dipeptidyl peptidase-4) inhibitor under development by Takeda for the treatment of type 2 diabetes (T2D).. Once-weekly Trelagliptin treatment produced clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes. It was well tolerated and might be a new treatment option for patients with this disease. Trelagliptin was approved in Japan for the treatment of type 2 diabetes mellitus (T2DM).

    In VivoTrelagliptin improves glycaemic control by inhibition of DPP-4 activity.
    Animal model
    Formulation & Dosage
    References

    Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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