| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
Rat brain homogenates show no reduction in lipid peroxidation when tolmetin sodium dihydrate (0.25 mM) is added. In rat brain homogenate, tolmetin (0.25, 0.5, 0.75, and 1 mM) demonstrates free radical scavenging activities without producing superoxide anion [3]. The HT-29 colon cancer cell line is susceptible to dose-dependent anticancer action from tolmetin sodium dihydrate (0.001-100 μM) [4]. On osteoblast development, tolmetin sodium dihydrate (0-100 μM) has little effect [5].
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|---|---|
| ln Vivo |
Maximum ulcerogenic effects were observed 4 hours after a single dose of tolmetin sodium dihydrate (30,100 mg/kg; gavage; once or twice daily for 3 and 14 days). In male Wistar rats weighing 180 g, the ulcerogenic effect of -200 g was significantly reduced after repeated administration for 3 and 14 days. At 100 mg/kg, tolmetin can induce stomach injury [2]. Quinolinic acid (QA)-induced neurotoxicity was considerably reduced when tolmetin sodium dihydrate (5 mg/kg twice day for 5 days) was administered beforehand [3].
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| References |
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| Additional Infomation |
Tolmetin sodium dihydrate is an organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a non-steroidal anti-inflammatory drug. It is an organic sodium salt and a hydrate. It contains a tolmetin sodium.
See also: Tolmetin Sodium (annotation moved to). |
| Molecular Formula |
C15H14NO3-.NA+.2[H2O]
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|---|---|
| Molecular Weight |
315.29692
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| Exact Mass |
315.108
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| CAS # |
64490-92-2
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| Related CAS # |
Tolmetin;26171-23-3;Tolmetin sodium;35711-34-3
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| PubChem CID |
23677829
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| Appearance |
Light yellow to yellow solid powder
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| Boiling Point |
483.2ºC at 760 mmHg
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| Melting Point |
155-157 (dec.)
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| Flash Point |
246ºC
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| LogP |
0.728
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
22
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| Complexity |
353
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
QQILXENAYPUNEA-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1
|
| Chemical Name |
sodium;2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate;dihydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~317.16 mM)
DMSO : ~12.5 mg/mL (~39.64 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (3.96 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (3.96 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.25 mg/mL (3.96 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 25 mg/mL (79.29 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1716 mL | 15.8579 mL | 31.7158 mL | |
| 5 mM | 0.6343 mL | 3.1716 mL | 6.3432 mL | |
| 10 mM | 0.3172 mL | 1.5858 mL | 3.1716 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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