| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| Other Sizes |
| ln Vivo |
(±)-alpha-tocopheryl acetate ((±)-vitamin E acetate) (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15, 30, and 45 days) demonstrated considerable High complement activity[1]. (±)-α-Tocopherol acetate (orally; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15, 30, and 45 days) promotes nonspecific immunity in sea bream after 30 days of in vivo fish delivery system. Diet (1200 mg/kg) [1].
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| Animal Protocol |
Animal/Disease Models: Gilthead seabream (Sparus aurata L.) [1]
Doses: 600 mg/kg, 1200 mg/kg, 1800 mg/kg Route of Administration: oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg kg; 15-day, 30-day and 45-day Experimental Results: positively correlated with serum α-tocopherol levels, and the increase is related to dose and time of use. They did not show an enhancement in any immune parameter, while the specific growth rate of fish fed the diet supplemented with 1200 mg/kg was slightly higher (but not statistically significant) than that of fish fed the other diets. After 30 and 45 days, dietary intake of 1200 mg/kg enhanced serum hemolytic activity and phagocytosis of head kidney leukocytes, but leukocyte migration and respiratory burst activity were not affected. Does not cause immune stimulation at 1800 mg/kg. |
| References | |
| Additional Infomation |
DL-α-Tocopherol acetate is a tocopherol. It has been reported that DL-α-tocopherol acetate is found in catechu (Senegalia catechu), and relevant data exists. Vitamin E acetate is an acetate of the fat-soluble vitamin E, possessing potent antioxidant properties. Vitamin E is considered essential for stabilizing biological membranes, especially those rich in polyunsaturated fatty acids. It is a collective term for tocopherols and tocotrienols (collectively known as tocopherols). Vitamin E is a potent superoxide radical scavenger, capable of non-competitively inhibiting cyclooxygenase activity in various tissues, thereby reducing prostaglandin production. Vitamin E can also inhibit angiogenesis and tumor dormancy by inhibiting vascular endothelial growth factor (VEGF) gene transcription. (NCI04) It is a natural tocopherol and one of the most effective antioxidants. α-Tocopherol possesses antioxidant activity due to the phenolic hydroxyl group on its 2H-1-benzopyran-6-ol core. Its 6-chromoyl alcohol core has four methyl groups. Natural d-α-tocopherol is more active than its synthetic racemic mixture of dl-α-tocopherol.
See also: α-tocopherol acetate (note moved here). |
| Molecular Formula |
C31H52O3
|
|---|---|
| Molecular Weight |
472.7428
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| Exact Mass |
472.391
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| CAS # |
7695-91-2
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| Related CAS # |
D-α-Tocopherol acetate;58-95-7;DL-α-Tocopherol acetate;52225-20-4
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| PubChem CID |
2117
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| Appearance |
Colorless to light yellow viscous liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
485.3±0.0 °C at 760 mmHg
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| Melting Point |
-28ºC
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| Flash Point |
235.6±24.7 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.488
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| LogP |
12.07
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
34
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| Complexity |
602
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| Defined Atom Stereocenter Count |
0
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| SMILES |
0
|
| InChi Key |
ZAKOWWREFLAJOT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3
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| Chemical Name |
[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] acetate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~211.53 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (5.29 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (5.29 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.29 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1153 mL | 10.5766 mL | 21.1533 mL | |
| 5 mM | 0.4231 mL | 2.1153 mL | 4.2307 mL | |
| 10 mM | 0.2115 mL | 1.0577 mL | 2.1153 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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