| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| ln Vivo |
In dogs with coronary artery blockage who are not under anesthesia, tocainide (100 mg/kg) significantly decreases ventricular ectopic activity. Ventricular ectopic activity recovered quickly after the tocainide infusion was stopped in models of coronary occlusion and digitalis toxicity [1].
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| References |
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| Additional Infomation |
Tocainide Hydrochloride is the hydrochloride salt form of tocainide, a primary amine analog of lidocaine exhibiting class 1b antiarrhythmic property. Tocainide hydrochloride stabilizes the neuronal membrane by reversibly binding to and blocking open and inactivated voltage-gated sodium channels. This inhibits the inward sodium current required for the initiation and conduction of impulses and reduces the excitability of myocardial cells. This agent reduces the rate of rise and amplitude, and shortens the action-potential duration (APD) in both the Purkinje and muscle fibers. Tocainide also shortens the effective refractory period (ERP) of Purkinje fibers resulting in an increased the ERP/APD ratio. Overall these effects lead to the slowing of nerve impulses and stabilization of the heartbeat.
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS. |
| Molecular Formula |
C11H17CLN2O
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|---|---|
| Molecular Weight |
228.72
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| Exact Mass |
192.126
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| CAS # |
71395-14-7
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| Related CAS # |
Tocainide;41708-72-9
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| PubChem CID |
108173
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| Appearance |
Off-white to gray solid powder
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| LogP |
2.362
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
15
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| Complexity |
196
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
AMZACPWEJDQXGW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
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| Chemical Name |
(1)-2-Amino-N-(2,6-dimethylphenyl)propionamide hydrochloride
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| Synonyms |
Alanyl-2,6-xylidide Astra W 36095 W36095 W 36095W-36095Tocainide hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~546.52 mM)
H2O : ~50 mg/mL (~218.61 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (9.09 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (9.09 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (9.09 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3722 mL | 21.8608 mL | 43.7216 mL | |
| 5 mM | 0.8744 mL | 4.3722 mL | 8.7443 mL | |
| 10 mM | 0.4372 mL | 2.1861 mL | 4.3722 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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