| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| Other Sizes |
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| ln Vitro |
Tiamulin fumarate, a semisynthetic substitute for the diterpenoid antibiotic pleuromutilin, is useful for researching neck inflammation, which is primarily brought on by mycoplasma [1]. Tiamulin is Gram Active against Gram-positive bacteria (Staphylococcus, Streptococcus, Clostridium, Mysterella), but it is less effective against Gram-negative bacteria (Pasteurella, Klebsiella, Haemophilus, Clostridium, Campylobacter, Bacteroidetes)[1]. It is also active in vitro against strains of mycoplasma (Mycoplasma gallisepticum, Mycoplasma synoviae, M. meleagridis, and M. iowae), spirochetes (Brachyspira porcine diarrhea, Brachyspira asexualis, Brachyspira pilosa, and Brachyspira intermedius), and mycoplasma strains of mycoplasma. In ribosomal peptidyl transfer groove enzymes, trimulin fumarate binds to rRNA, preventing tRNA's CCA termination from being correctly positioned to support peptidyl transferase and the subsequent synthesis of protein [1].
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| ln Vivo |
Treatment of poultry-destroying spirochete illness in breeders and laying hens using tiamulin fumarate (25 mg/kg for 5 days) proved highly efficient in a trial including artificial infections with B. trichocystis and B. intermedius [1].
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| References |
[1]. Dreyfuss J, et al. Metabolism of tritium- and carbon-14-labeled tiamulin in dogs, rats, and pigs. J Antibiot (Tokyo). 1979 May;32(5):496-503.
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| Molecular Formula |
C28H47NO4S.C4H4O4
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|---|---|
| Molecular Weight |
609.814
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| Exact Mass |
609.33
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| Elemental Analysis |
C, 63.03; H, 8.43; N, 2.30; O, 20.99; S, 5.26
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| CAS # |
55297-96-6
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| Related CAS # |
Tiamulin;55297-95-5
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| Appearance |
Solid powder
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| SMILES |
(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((2-(diethylamino)ethyl)thio)acetate Fumarate
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| InChi Key |
YXQXDXAHCSEVSD-GCYNEOGWSA-N
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| InChi Code |
InChI=1S/C28H47NO4S.C4H4O4/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28;5-3(6)1-2-4(7)8/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t19-,20+,22-,24+,25+,26-,27+,28+;/m1./s1
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| Chemical Name |
(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((2-(diethylamino)ethyl)thio)acetate Fumarate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~163.99 mM)
H2O : ~100 mg/mL (~163.99 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.10 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.10 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (4.10 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (163.99 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6399 mL | 8.1993 mL | 16.3986 mL | |
| 5 mM | 0.3280 mL | 1.6399 mL | 3.2797 mL | |
| 10 mM | 0.1640 mL | 0.8199 mL | 1.6399 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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