| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Thiamphenicol glycinate hydrochloride targets bacterial ribosomes. It acts as a broad-spectrum antibacterial agent by inhibiting bacterial protein synthesis. It affects respiratory pathogens and is used for the treatment of acute lower respiratory tract infections.
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|---|---|
| ln Vitro |
In vitro, Thiamphenicol glycinate hydrochloride is active against a broad spectrum of respiratory pathogens. The compound is a broad-spectrum antibacterial agent. Specific IC50 or MIC values are not provided in the available sources.
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| ln Vivo |
In vivo, Thiamphenicol glycinate hydrochloride can be used for the treatment of acute lower respiratory tract infections. The compound is active in vivo. Specific animal models and efficacy data are not detailed in the available sources.
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| Enzyme Assay |
The in vitro antibacterial susceptibility assay for Thiamphenicol glycinate hydrochloride involves testing its activity against bacterial pathogens. Bacteria are cultured in the presence of varying compound concentrations, and the minimum inhibitory concentration (MIC) is determined by assessing bacterial growth inhibition.
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| Cell Assay |
Cellular assays for Thiamphenicol glycinate hydrochloride are not typically performed, as it is an antibacterial agent. Activity is assessed directly on bacterial cultures rather than on mammalian cells.
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| Animal Protocol |
In vivo animal studies for Thiamphenicol glycinate hydrochloride are not detailed in the available sources. The compound is used for the treatment of respiratory infections, but specific animal models and dosing regimens are not described.
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| ADME/Pharmacokinetics |
Thiamphenicol glycinate hydrochloride is administered orally or parenterally. The compound is soluble in DMSO at 250 mg/mL (555.89 mM). Powder formulations should be stored at -20°C for up to 3 years or at 4°C for up to 2 years; solutions should be stored at -80°C for up to 6 months or at -20°C for up to 1 month.
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| Toxicity/Toxicokinetics |
Toxicity data for Thiamphenicol glycinate hydrochloride are not detailed in the available sources. As a broad-spectrum antibacterial agent, it is generally well-tolerated. Specific toxicological profiles have not been characterized in the supplier documentation.
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| References | |
| Additional Infomation |
Thiamphenicol glycinate hydrochloride is an antibacterial agent used for the treatment of respiratory infections. It is a glycinate ester of thiamphenicol. The compound is available from chemical suppliers for research purposes.
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| Molecular Formula |
C14H19CL3N2O6S
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|---|---|
| Molecular Weight |
449.7345
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| Exact Mass |
448.002
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| CAS # |
2611-61-2
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| Related CAS # |
Thiamphenicol glycinate;2393-92-2
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| PubChem CID |
197006
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| Appearance |
White to off-white solid powder
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| Boiling Point |
672.5ºC at 760 mmHg
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| Flash Point |
360.5ºC
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| Vapour Pressure |
5.26E-19mmHg at 25°C
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| LogP |
2.887
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
26
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| Complexity |
558
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| Defined Atom Stereocenter Count |
2
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| SMILES |
CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](COC(=O)CN)NC(=O)C(Cl)Cl)O.Cl
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| InChi Key |
DKXJDBJNAXSJDH-MHDYBILJSA-N
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| InChi Code |
InChI=1S/C14H18Cl2N2O6S.ClH/c1-25(22,23)9-4-2-8(3-5-9)12(20)10(7-24-11(19)6-17)18-14(21)13(15)16;/h2-5,10,12-13,20H,6-7,17H2,1H3,(H,18,21);1H/t10-,12-;/m1./s1
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| Chemical Name |
[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-methylsulfonylphenyl)propyl] 2-aminoacetate;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~555.89 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (4.62 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2236 mL | 11.1178 mL | 22.2356 mL | |
| 5 mM | 0.4447 mL | 2.2236 mL | 4.4471 mL | |
| 10 mM | 0.2224 mL | 1.1118 mL | 2.2236 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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