My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    TH287
    TH287

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1893
    CAS #: 1609960-30-6Purity ≥98%

    Description: TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM. TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. In U2OS and other cancer cell lines, TH287 treatment selectively and effectively kill cancer cells with less toxic to some primary or immortalized cells. U2OS cells treated with TH287 shows increase of 8-oxodG in DNA. The MTH1 inhibitor TH287 induces DNA damage and activates an ATM-p53-mediated death response and DNA repair in U2OS cells. 

    References: Nature. 2014 Apr 10;508(7495):215-21; J Pharm Biomed Anal. 2015 Feb;104:1-11.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)269.13 
    FormulaC11H10Cl2N4 
    CAS No.1609960-30-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 53 mg/mL (196.9 mM) 
    Water: <1 mg/mL
    Ethanol: 10 mg/mL (37.2 mM) 
    Other info

    Chemical Name: 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine

    InChi Key: URWCXPXBBITYLR-UHFFFAOYSA-N

    InChi Code: InChI=1S/C11H10Cl2N4/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13/h2-5H,1H3,(H3,14,15,16,17)

    SMILES Code: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1

    SynonymsTH287; TH 287; TH-287.


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage.


    Cell Assay: In U2OS and other cancer cell lines, TH287 treatment selectively and effectively kill cancer cells with less toxic to some primary or immortalized cells. U2OS cells treated with TH287 shows increase of 8-oxodG in DNA. The MTH1 inhibitor TH287 induces DNA damage and activates an ATM-p53-mediated death response and DNA repair in U2OS cells. 

    In VivoIn C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82μM.  
    Animal modelC57Bl/6 mice 
    Formulation & DosageDissolved in 1% DMSO, 10% ethanol, 10% Chremophore EL and 10% Tween-80 and diluted with PBS; 5 mg/kg; i.p. injection.
    References

    Nature. 2014 Apr 10;508(7495):215-21; J Pharm Biomed Anal. 2015 Feb;104:1-11. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?