| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| Other Sizes |
| ln Vitro |
In vitro, Tetradecanedioic acid is primarily used as a chemical reagent and industrial intermediate rather than as a pharmacological agent. It is an α,ω-dicarboxylic acid and a human metabolic byproduct. The compound's in vitro activity is related to its chemical properties as a long-chain dicarboxylic acid rather than specific biological effects. It may be used in biochemical studies of fatty acid metabolism as a substrate or reference compound. Tetradecanedioic acid is also used in the synthesis of synthetic fragrances and high-grade engineering plastics. Its role as an endogenously produced metabolite suggests it may participate in normal metabolic processes, though its specific biological functions require further investigation.
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|---|---|
| ln Vivo |
In vivo, Tetradecanedioic acid is an endogenously produced metabolite and a human metabolic byproduct. As a long-chain dicarboxylic acid, it is formed by the oxidation of fatty acids and may be involved in fatty acid metabolism pathways. The compound is primarily used industrially for the synthesis of synthetic fragrances, high-grade engineering plastics such as nylon 1414, hot-melt adhesives, and coatings. It is not used therapeutically. The compound's presence in humans reflects its role as a metabolic intermediate in fatty acid oxidation. Further research is needed to elucidate its physiological functions and potential biological activities.
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| Enzyme Assay |
In vitro enzyme/receptor binding (non-cellular) assays are not applicable to Tetradecanedioic acid, as it is primarily a chemical reagent and industrial intermediate rather than a bioactive compound. However, the compound may be used as a substrate or reference standard in studies of fatty acid metabolism. Enzyme activity assays for fatty acid oxidation enzymes (e.g., acyl-CoA synthetase, acyl-CoA dehydrogenase) may use dicarboxylic acids as substrates. The compound's chemical properties make it useful as a building block in organic synthesis. Its role as an endogenously produced metabolite suggests it may be relevant to studies of metabolic pathways, but specific pharmacological assays are not established.
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| Cell Assay |
In vitro cellular experiments with Tetradecanedioic acid are not typically performed for pharmacological evaluation, as the compound is primarily a chemical reagent and industrial intermediate. However, cellular studies of fatty acid metabolism may use the compound as a substrate or metabolite for investigating dicarboxylic acid transport, metabolism, or toxicity. Cell lines such as hepatocytes or adipocytes may be treated with varying concentrations of the compound, and effects on lipid metabolism, energy production, or cell viability may be assessed. The compound's role as a human metabolic byproduct makes it relevant to studies of metabolic disorders.
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| Animal Protocol |
In vivo animal studies with Tetradecanedioic acid are not typically performed for therapeutic development, as the compound is primarily an industrial intermediate and chemical reagent. However, metabolic studies may investigate the compound's role as an endogenously produced metabolite. Animals may be administered the compound to study its metabolism, tissue distribution, and excretion. As a dicarboxylic acid, it would be expected to be metabolized through β-oxidation pathways. However, detailed in vivo pharmacokinetic and toxicological data are not extensively reported. The compound is intended for industrial and research use only.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Tetradecanedioic acid are not extensively characterized for therapeutic applications. The compound has molecular formula C₁₄H₂₆O₄ and molecular weight 258.35 g/mol. It appears as a white to almost white powder to crystal with a melting point of 125-128°C. Purity: min. 95.0% (GC) or min. 98.0% (neutralization titration). Storage: room temperature (below 15°C in a cool, dry place). As a dicarboxylic acid with a 14-carbon chain, it is expected to have limited water solubility and moderate lipophilicity. It is primarily used as an industrial intermediate and chemical reagent. Detailed pharmacokinetic parameters require further investigation.
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| Toxicity/Toxicokinetics |
Toxicological information for Tetradecanedioic acid is not extensively detailed in the available literature. The compound appears as a white to almost white powder to crystal. As a dicarboxylic acid, it may cause skin, eye, or respiratory irritation at high concentrations. Standard safety precautions for handling research chemicals apply, including use of personal protective equipment (gloves, safety goggles, lab coat) and working in a well-ventilated area. The compound is primarily used as an industrial intermediate and is not approved for human therapeutic use. Storage: room temperature (below 15°C in a cool, dry place).
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| References | |
| Additional Infomation |
Tetradecanedioic acid is an α,ω-dicarboxylic acid, a product of the oxidation of the methyl group in tetradecane to the corresponding carboxylic acid. It is a human metabolic byproduct. It is both an α,ω-dicarboxylic acid and a dicarboxylic acid fatty acid. It is the conjugate acid of Tetradecanedioic acid ester (2-). It is derived from the hydride of tetradecane. Tetradecanedioic acid has been reported to exist in fruit flies, Arabidopsis thaliana, and radiata pine, and relevant data are available.
Tetradecanedioic acid (CAS 821-38-5) is an α,ω-dicarboxylic acid and an endogenously produced metabolite. The compound has molecular formula C₁₄H₂₆O₄ and molecular weight 258.35 g/mol. It appears as a white to almost white powder to crystal with a melting point of 125-128°C. Tetradecanedioic acid is a long-chain fatty acid organic/chemical reagent produced by oxidation of tetradecane. It is a human metabolic byproduct. The compound is used in the synthesis of synthetic fragrances, high-grade engineering plastics such as nylon 1414, hot-melt adhesives, and coatings. Purity: min. 98.0%. Storage: room temperature (below 15°C in a cool, dry place). |
| Molecular Formula |
C14H26O4
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|---|---|
| Molecular Weight |
258.3538
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| Exact Mass |
258.183
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| CAS # |
821-38-5
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| Related CAS # |
Tetradecanedioic acid-d24;130348-88-8
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| PubChem CID |
13185
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| Appearance |
White to off-white solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
434.1±18.0 °C at 760 mmHg
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| Melting Point |
124-127 °C(lit.)
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| Flash Point |
230.5±17.7 °C
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| Vapour Pressure |
0.0±2.2 mmHg at 25°C
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| Index of Refraction |
1.475
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| LogP |
3.99
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
13
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| Heavy Atom Count |
18
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| Complexity |
202
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
HQHCYKULIHKCEB-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C14H26O4/c15-13(16)11-9-7-5-3-1-2-4-6-8-10-12-14(17)18/h1-12H2,(H,15,16)(H,17,18)
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| Chemical Name |
tetradecanedioic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~193.53 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (9.68 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.68 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8707 mL | 19.3536 mL | 38.7072 mL | |
| 5 mM | 0.7741 mL | 3.8707 mL | 7.7414 mL | |
| 10 mM | 0.3871 mL | 1.9354 mL | 3.8707 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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