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    Tenovin-6
    Tenovin-6

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0022
    CAS #: 1011557-82-6Purity ≥98%

    Description: Tenovin-6 is an analog of tenovin-1 with higher water-solubility and has potential anticancer activity. It acts by inhibiting the protein deacetylase activities of SIRT1, SIRT2 and SIRT3 with IC50 value of 21 μM, 10 μM, and 67 μM, respectively. The cytotoxic effects of tenovin-6 occurs through the dysregulation of autophagy rathe than induction of apoptosis in chronic lymphocytic leukemia cells. 

    References: Cancer Cell. 2008 May;13(5):454-63.

    Related CAS: 1011301-29-3 (HCl)

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    Molecular Weight (MW)454.63
    FormulaC25H34N4O2S
    CAS No.1011557-82-6
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 98 mg/mL (215.55 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: <1 mg/mL (slightly soluble or insoluble)
    Solubility (In vivo)Tenovin-6; Tenovin 6; Tenovin6


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    GeneralTenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively.
    Animal modelARN8 melanoma cells were injected into the flank of SCID mice and allowed to develop into tumors. 
    Formulation
    Dosages 50 mg/kg
    Administration i.p.
    References[1] Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Tenovin-6
    Tenovin-6 Delays Tumor Growth In Vivo. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.
     
    Tenovin-6
    Tenovin-6 Inhibits the Protein Deacetylase Activities of Purified Sirtuins SirT1 and SirT2


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