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      Tenovin-1
      Tenovin-1

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      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V0016
      CAS #: 380315-80-0Purity ≥98%

      Description: Tenovin-1, a small molecule compound discovered by a cell-based screen, is a novel and potent activator of p53 that protects against MDM2-mediated p53 degradation. It acts by inhibiting the protein-deacetylating activities of SirT1 and SirT2, and elevating the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. 

      Reference: Cancer Cell. 2008 May;13(5):454-63. 

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      Molecular Weight (MW)369.48
      FormulaC20H23N3O2S
      CAS No.380315-80-0
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 74 mg/mL (200.28 mM)
      Water:<1 mg/mL (slightly soluble or insoluble)
      Ethanol:<1 mg/mL
      Solubility (In vivo)15% Captisol: 15 mg/mL
      SynonymsTenovin-1; Tenovin1; Tenovin 1 


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      GeneralInitial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
      Animal modelFemale SCID mice injected subcutaneously with ARN8 cells suspended in matrigel.
      FormulationFormulated in 70% cyclodextrin
      Dosages92.5 mg/kg
      Administrationi.p.
      References[1] Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      Tenovin-1

      		 

      Tenovin-1

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