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Description: Tenovin-1, a small molecule compound discovered by a cell-based screen, is a novel and potent activator of p53 that protects against MDM2-mediated p53 degradation. It acts by inhibiting the protein-deacetylating activities of SirT1 and SirT2, and elevating the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis.
Reference: Cancer Cell. 2008 May;13(5):454-63.
Product Catalog 2022
Guide to Product Handling
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS