| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
TEMPO does not have a specific biological target. It is a chemical reagent used as an oxidation catalyst in organic synthesis. The compound is a stable nitroxyl radical that can participate in redox reactions, acting as a one-electron oxidant. Its mechanism is based on its radical nature, allowing it to catalyze the oxidation of various substrates.
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| ln Vitro |
In vitro, TEMPO is used as a chemical reagent and oxidation catalyst. Its reactivity is characterized by its ability to oxidize alcohols to aldehydes and ketones in the presence of co-oxidants. The compound is not typically evaluated for biological activity as it is not a drug candidate. It is widely used in organic synthesis for selective oxidations.
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| ln Vivo |
In vivo, TEMPO is not used as a therapeutic agent. It is used as a chemical reagent in laboratory and industrial applications. The compound is not administered to animals or humans for pharmacological purposes. Any biological activity would be incidental and not the primary purpose of the compound.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not typically performed for TEMPO, as it is not a bioactive compound. The compound is used as a chemical reagent and oxidation catalyst. Its purity and chemical properties are characterized by standard analytical techniques including NMR, HPLC, and mass spectrometry rather than by biological assays.
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| Cell Assay |
In vitro cell-based assays are not applicable for TEMPO as it is not a pharmacologically active compound. The compound is used in chemical synthesis and as an oxidation catalyst. It is not evaluated for its effects on cell viability, proliferation, or other cellular functions. It is not intended for use in cell culture or biological research applications.
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| Animal Protocol |
In vivo animal studies are not performed for TEMPO as it is not a pharmacologically active compound. The compound is used as a chemical reagent and is not intended for therapeutic use. Any animal studies involving this compound would be limited to toxicological evaluations for occupational safety or environmental impact.
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| ADME/Pharmacokinetics |
TEMPO has a molecular formula of C9H18NO and a molecular weight of 156.25. It is a red-orange sublimable solid that is soluble in organic solvents. The compound is stored at room temperature in a cool, dark place. It is used as a chemical reagent for the selective oxidation of alcohols to aldehydes and ketones. The compound is stable under normal storage conditions.
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| Toxicity/Toxicokinetics |
The toxicity profile of TEMPO is characterized in standard safety data sheets for handling and occupational exposure. The compound may cause skin and eye irritation upon contact. Appropriate safety precautions should be taken during handling. The compound is not classified as a hazardous substance at typical use concentrations. It should be stored and used in accordance with standard laboratory safety practices.
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| References |
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| Additional Infomation |
TEMPO belongs to the aminooxyacyl group of compounds, with an oxidized diacyl group attached to the piperidine ring at position 1 and a methyl group attached to positions 2, 2, 6, and 6. It exhibits inhibitory effects on ferroptosis, catalytic activity, and free radical scavenging. TEMPO belongs to both the piperidine and aminooxyacyl groups.
TEMPO (2,2,6,6-tetramethylpiperidin-1-yl)oxyl is a stable free radical and a widely used oxidation catalyst. It is a red-orange sublimable solid used as a chemical reagent in organic synthesis for the selective oxidation of alcohols to aldehydes and ketones. TEMPO is also used in polymer chemistry and as a spin label in electron paramagnetic resonance (EPR) spectroscopy. It is used for research and industrial purposes. |
| Molecular Formula |
C9H18NO
|
|---|---|
| Molecular Weight |
156.25
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| Exact Mass |
156.138
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| CAS # |
2564-83-2
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| Related CAS # |
Tempo-d18;205679-68-1
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| PubChem CID |
2724126
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| Appearance |
Orange to red solid powder
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| Density |
1 g/cm3
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| Boiling Point |
193°C
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| Melting Point |
36-38 °C(lit.)
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| Flash Point |
154 °F
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| LogP |
2.312
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
11
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| Complexity |
136
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
QYTDEUPAUMOIOP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H18NO/c1-8(2)6-5-7-9(3,4)10(8)11/h5-7H2,1-4H3
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| Synonyms |
AI351508; AI3 51508; AI3-51508
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~640.00 mM)
DMSO : ~100 mg/mL (~640.00 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.00 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.00 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.00 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.4000 mL | 32.0000 mL | 64.0000 mL | |
| 5 mM | 1.2800 mL | 6.4000 mL | 12.8000 mL | |
| 10 mM | 0.6400 mL | 3.2000 mL | 6.4000 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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