Absorption, Distribution and Excretion
Skin permeability of 14C-labeled termethin was determined in mice, rabbits, and dogs. Absorption was assessed by monitoring radioactivity excreted in urine and feces over 7 days and analyzing tissue samples. The expected absorption was less than 3% of the administered dose. No evidence of radioactive material retention or accumulation in the body was found. In guinea pigs, oral absorption was significantly lower than in mice, and bile excretion of metabolites was confirmed. When mice were orally administered 3H-labeled termethin, blood radioactivity peaked between 5 and 8 hours and then dissipated within a half-life of approximately 10 hours. Significant radioactivity was found only in the gastrointestinal tract and fat. In feces and fat, most of the radioactivity originated from unmetabolized pesticides, but trace amounts of sulfoxides were also present. Trace amounts of termethin were found in urine… In mammals, termethin is primarily excreted in unmetabolized form via feces and urine.
Metabolisms/Metabolites
Studies using tritium-labeled abatazone showed that this insecticide is relatively resistant to metabolic degradation. Residue on bean leaves… consisted primarily of intact abatazone, representing approximately 70% of the applied dose. The main metabolite was a sulfoxide derivative, accounting for less than 5% of the dose. Trace amounts of sulfone derivatives, oxygen analogs, and glycosidic conjugates of the phenolic hydrolysates of abatazone and its sulfoxide and sulfone derivatives were also observed.
When rats were fed abatazone, 60% of the substance appeared in feces as oxygen analogs of abatazone and its sulfoxide. Thiodiols, sulfinyldiols, and sulfonyldiols were also detected. In urine, sulfate and glucosinolate conjugates of the hydrolysates of abatazone and its sulfoxide, as well as sulfone analogs, accounted for 39.5% of the total administered dose. …Five compounds found in feces and three compounds found in urine were not identified.
Aedes aegypti L. larvae metabolize abat to abat sulfoxides and sulfones, oxygen analogs and demethyl analogs. Some conjugates are also generated. In vitro, all expected metabolites are present in vivo as intact esters or hydrolysates...
Abbat production, abat sulfoxides and thiodiols in rats. /Excerpt from Table/
For more complete metabolite/metabolite data for TEMEPHOS (8 in total), please visit the HSDB record page.

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Biological half-life
When (3)H temetphos was administered orally to rats, the radioactivity in the blood peaked between 5 and 8 hours and then dissipated with a half-life of about 10 hours.

Interactions
The mixture of abat and malathion was significantly more toxic to rats than either compound alone. Non-human Toxicity Values Dermal LD50 for female rabbits: 970 mg/kg; Dermal LD50 for male rabbits: 1930 mg/kg; Oral LD50 for male rats: 8600 mg/kg; Oral LD50 for female rats: 13,000 mg/kg. For more complete non-human toxicity data for TEMEPHOS (15 compounds), please visit the HSDB record page.

Terfenoxam appears as a white crystalline solid or liquid (above 87 °F). It is used as an insecticide. Industrial grade is a viscous brown liquid. (NIOSH, 2024)
Terfenoxam is an organosulfur compound, a diphenyl sulfide, in which the hydrogen at the para-position of each phenyl group is replaced by an oxygen group (dimethoxyphosphothiophosphate). It can be used as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, acaricide, agricultural chemical, and ectoparasite killer. It is an organothiophosphate, organothiophosphate insecticide, and organosulfur compound. It is functionally related to 4,4'-thiodiphenol.
Diphosphothiophosphate has been used in studies investigating the treatment of malaria with Plasmodium falciparum.
An organothiophosphate insecticide.
Mechanism of Action

Abet is a cholinesterase inhibitor insecticide. Organophosphate insecticides primarily poison insects and humans by phosphorylating acetylcholinesterase in nerve endings. /Organophosphate cholinesterase inhibitor insecticides/

C16H20O6P2S3

466.46

465.989

3383-96-8

Temephos-d12;1219795-39-7

5392

Colorless crystals
White, crystalline solid or liquid (above 87 degrees F) [Note: Technical grade is a brown, viscous liquid].

1.4±0.1 g/cm3

518.5±60.0 °C at 760 mmHg

30-31°C

267.4±32.9 °C

0.0±1.3 mmHg at 25°C

1.613

5.96

0

9

10

27

474

0

COP(OC(C=C1)=CC=C1SC2=CC=C(OP(OC)(OC)=S)C=C2)(OC)=S

WWJZWCUNLNYYAU-UHFFFAOYSA-N

InChI=1S/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3

[4-(4-dimethoxyphosphinothioyloxyphenyl)sulfanylphenoxy]-dimethoxy-sulfanylidene-λ5-phosphane

Bithion; Abate; Temefos

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

DMSO : ~100 mg/mL (~214.38 mM)

Solubility in Formulation 1: 2.5 mg/mL (5.36 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

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Solubility in Formulation 2: ≥ 2.5 mg/mL (5.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.

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 (Please use freshly prepared in vivo formulations for optimal results.)