| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Our in vitro tests reveal that the title chemical (Telomerase-IN-1) has high inhibitory action against telomerase, high anti-proliferation ability on SMMC-7721 cells, and no clear harmful effects on normal human liver cells. Telomerase-IN-1 therapy inhibited cancer cell proliferation in a dose- and time-dependent manner; however, the viability of L-02 showed minimal modifications at 10 μM. Treatment of SMMC-7721 cells with telomerase-IN-1 (20, 40, and 80 nM) for 48 hours resulted in enhanced apoptosis. Treatment of SMMC-7721 cells with telomerase-IN-1 (20, 40, and 80 nM) for 48 hours resulted in a considerable accumulation of green fluorescence, indicating a reduction in MMPs. At 40 nM, telomerase-IN-1 dramatically boosts the expression of cyt-c and Bax, but reduces Bcl-2 levels [1].
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| ln Vivo |
Our in vivo research demonstrates that telomerase-IN-1 considerably suppresses the growth of tumors in xenograft models. The findings demonstrate how endoplasmic reticulum stress (ERS) triggers the expression of hTERT via endoplasmic reticulum excessive response (EOR). ERS is thought to be closely linked to oxidative stress and mitochondrial dysfunction, which ultimately cause apoptosis. As a result, ERS regulates apoptosis. Cell proliferation is inhibited as a result of the production of downstream signaling molecules, such as the mitochondrial apoptosis pathway and CHOP (CAAT/enhancer binding protein homologous protein) [1].
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| References |
| Molecular Formula |
C21H23FN2O4
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|---|---|
| Molecular Weight |
386.416729211807
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| Exact Mass |
386.164
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| CAS # |
666859-49-0
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| PubChem CID |
10475235
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
512.7±50.0 °C at 760 mmHg
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| Flash Point |
263.9±30.1 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
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| Index of Refraction |
1.573
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| LogP |
3.62
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
28
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| Complexity |
517
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
FDXXXOGKSMENLY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H23FN2O4/c1-28-20(15-4-8-19(9-5-15)24(26)27)14-23-12-10-17(11-13-23)21(25)16-2-6-18(22)7-3-16/h2-9,17,20H,10-14H2,1H3
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| Chemical Name |
(4-fluorophenyl)-[1-[2-methoxy-2-(4-nitrophenyl)ethyl]piperidin-4-yl]methanone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~258.79 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.47 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5879 mL | 12.9393 mL | 25.8786 mL | |
| 5 mM | 0.5176 mL | 2.5879 mL | 5.1757 mL | |
| 10 mM | 0.2588 mL | 1.2939 mL | 2.5879 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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