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    Telithromycin
     Telithromycin

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4413
    CAS #: 191114-48-4Purity ≥98%

    Description: Telithromycin (also known as HMR-3647 and RU-66647) is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant safety concerns, the US Food and Drug Administration sharply curtailed the approved uses of the drug in early 2007. Telithromycin is a semi-synthetic erythromycin derivative. It is created by substituting a ketogroup for the cladinose sugar and adding a carbamate ring in the lactone ring. An alkyl-aryl moiety is attached to this carbamate ring. Furthermore, the carbon at position 6 has been methylated, as is the case in clarithromycin, to achieve better acid-stability. 

    References: http://en.wikipedia.org/wiki/Telithromycin


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     Telithromycin

    Name: Telithromycin
    CAS#: 191114-48-4
    Chemical Formula: C43H65N5O10
    Exact Mass: 811.4731
    Molecular Weight: 812.018
    Elemental Analysis: C, 63.60; H, 8.07; N, 8.62; O, 19.70
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym:  HMR-3647; HMR 3647; HMR3647; RU-66647; RU 66647; RU66647
    IUPAC/Chemical Name: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)butyl)octahydro-2H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetraone
    InChi Key: LJVAJPDWBABPEJ-PNUFFHFMSA-N
    InChi Code: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1
    SMILES Code: O=C([[email protected]](C)C[[email protected]@](C)(OC)[[email protected]](O[[email protected]@H]1O[[email protected]](C)C[[email protected]](N(C)C)[[email protected]]1O)[[email protected]@H](C)C([[email protected]@H](C)C(O[[email protected]](CC)[[email protected]@]2(C)O3)=O)=O)[[email protected]](C)[[email protected]@]2([H])N(CCCCN4C=C(C5=CC=CN=C5)N=C4)C3=O


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