| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
Tectorigenin is an isoflavonoid plant that was first isolated from Pueraria thomsonii Benth's dried flowers. The formation of ROS generated by palmitic acid (PA) may be reduced by treating HUVECs with irisogenin at doses ranging from 0.1 to 10 μM. Irisogenin treatment reduced increased IKKβ phosphorylation and, at doses ranging from 0.1 to 10 μM, significantly inhibited NF-κB activation by p65 phosphorylation. In a concentration-dependent manner, irisogenin therapy also successfully reduced PA-enhanced TNF-α and IL-6 production [1]. Treatment with irisogenin resulted in a concentration- and time-dependent decrease in the number of viable HepG2 cells. HepG2 cells showed survival rates of 91%, 79%, and 62%, respectively, after being treated with 5, 10, and 20 mg/L irisogenin for 24 hours [2].
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| References |
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| Additional Infomation |
Tectorigenin is a methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 5, 7 and 4' respectively. It has a role as an anti-inflammatory agent and a plant metabolite. It is a member of 7-hydroxyisoflavones and a methoxyisoflavone. It is functionally related to an isoflavone.
Tectorigenin has been reported in Iris tectorum, Iris milesii, and other organisms with data available. Tectorigenin is an isoflavone from Pueraria thunbergiana, which induces differentiation and apoptosis in cancer cells. (NCI) |
| Exact Mass |
300.063
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|---|---|
| CAS # |
548-77-6
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| PubChem CID |
5281811
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.512
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| Boiling Point |
601.5±55.0 °C at 760 mmHg
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| Melting Point |
225-226°
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| Flash Point |
230.1±25.0 °C
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| Vapour Pressure |
0.0±1.8 mmHg at 25°C
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| Index of Refraction |
1.697
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| LogP |
2.54
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
22
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| Complexity |
454
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O1C([H])=C(C2C([H])=C([H])C(=C([H])C=2[H])O[H])C(C2C(=C(C(=C([H])C1=2)O[H])OC([H])([H])[H])O[H])=O
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| InChi Key |
OBBCRPUNCUPUOS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H12O6/c1-21-16-11(18)6-12-13(15(16)20)14(19)10(7-22-12)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3
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| Chemical Name |
5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxychromen-4-one
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| Synonyms |
Tectorigenin K251T K 251T
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~120 mg/mL (~399.65 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.93 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.93 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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