| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg | |||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
This study investigated the absorption, distribution, excretion, and metabolism of tertifene in rats. Tertifene is partially absorbed and rapidly excreted, without accumulating in tissues. Although tertifene is primarily excreted unchanged, several polar metabolites were identified. Metabolisms/Metabolites In rats, 16 complete molecular weight metabolites were formed due to the oxidation of aromatic cycloalkyl substituents (mainly at the benzylic position). In apples, grapes, rice, and beets, the main component is unchanged tertifene. A small number of detected metabolites were also produced by the oxidation of aromatic cycloalkyl substituents (mainly at the benzylic position). Although tertifene is primarily excreted unchanged, several polar metabolites were identified. These metabolites are products of the oxidation of the ethyl or methyl side chain at the benzylic position. These metabolites were detected in metabolic studies in plants and other animals (rats, goats, and chickens). A common metabolic pathway for terbutaline has been identified in both plants (grapes, apples, rice, and sugar beets) and animals (rats, goats, and chickens). This shared pathway involves the oxidation of alkyl substituents (ethyl and methyl) on the aromatic ring, primarily at the benzylic position. The polar metabolites undergo extensive degradation and elimination in animals, making accumulation in humans or animals exposed to these residues through diet unlikely. |
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| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (Rat) > 4,500 mg/m³/4h 5000 mg/kg LD50 (Rat) Dermal > 5000 mg/kg LC50 (Male Rat) Inhalation > 4.3 mg/L/4 hr LC50 (Female Rat) Inhalation > 4.5 mg/L/4 hr |
| Additional Infomation |
Terbutaline is a carbapenem compound with the structure hydrazine, in which the amino hydrogen is replaced by tert-butyl, 3,5-dimethylbenzoyl, and 4-ethylbenzoyl groups, respectively. It is a widely used insecticide for controlling caterpillars. It acts as an exogenous substance, environmental pollutant, and ecdysone agonist. Its function is similar to that of N'-benzoyl-N-(tert-butyl)benzoylhydrazine. Terbutaline is an insecticide that acts as an ecdysone agonist, causing premature molting in larvae. It is primarily used to control caterpillar pests.
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| Molecular Formula |
C22H28N2O2
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|---|---|
| Molecular Weight |
352.4699
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| Exact Mass |
352.215
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| CAS # |
112410-23-8
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| Related CAS # |
Tebufenozide-d9;2469006-89-9
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| PubChem CID |
91773
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| Appearance |
Off-white powder
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| Density |
1.1±0.1 g/cm3
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| Melting Point |
191ºC
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| Index of Refraction |
1.562
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| LogP |
4.24
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
26
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| Complexity |
479
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(C1C([H])=C(C([H])([H])[H])C([H])=C(C([H])([H])[H])C=1[H])N(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C(C1C([H])=C([H])C(C([H])([H])C([H])([H])[H])=C([H])C=1[H])=O
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| InChi Key |
QYPNKSZPJQQLRK-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C22H28N2O2/c1-7-17-8-10-18(11-9-17)20(25)23-24(22(4,5)6)21(26)19-13-15(2)12-16(3)14-19/h8-14H,7H2,1-6H3,(H,23,25)
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| Chemical Name |
N-tert-butyl-N'-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~354.64 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.90 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8371 mL | 14.1856 mL | 28.3712 mL | |
| 5 mM | 0.5674 mL | 2.8371 mL | 5.6742 mL | |
| 10 mM | 0.2837 mL | 1.4186 mL | 2.8371 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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