| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
Cell viability remains unaffected by TDCPP exposure at concentrations higher than 68 μg/mL. When exposed to 136 μg/mL TDCPP, HCEC displayed a 16% reduction in cell viability. Furthermore, TDCPP caused all viable cells to be completely reduced (87%) up until treatment to ≥272 μg/mL of TDCPP. TDCPP's LC50 value was determined by indirect regression analysis based on cell viability, and it was 202 μg/mL. Cell wetness increased in TDCPP-exposed cells at concentrations higher than in control cells. In comparison to controls, antioxidant Bcl-2 protein expression increased up to 1.4 times at 2 μg/mL TDCPP and 1.2 times at 20 μg/mL. times, but at 200 μg/mL, it dynamically dropped to 0.4 times. The quantity of caspase-3 activity introduced was 2.1 times greater than the control at 200 μg/mL TDCPP [1]. TDCPP affects cell viability and toxicity at similar values (IC50 = 171 μM and 168 μM, respectively), although it inhibits cell growth at lower concentrations (IC50 = 27 μM) [2].
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| References |
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| Additional Infomation |
Tris(1,3-dichloro-2-propyl) Phosphate (TDCPP) can cause cancer according to an independent committee of scientific and health experts.
Tris(1,3-dichloropropan-2-yl) phosphate is a trialkyl phosphate. See also: Tris(2,3-dichloropropyl) phosphate (annotation moved to). |
| Molecular Formula |
C9H15CL6O4P
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|---|---|
| Molecular Weight |
430.9048
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| Exact Mass |
427.883
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| CAS # |
13674-87-8
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| PubChem CID |
26177
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
457.4±40.0 °C at 760 mmHg
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| Melting Point |
-64°C
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| Flash Point |
377.7±35.0 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.497
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| LogP |
1.79
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
20
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| Complexity |
243
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ASLWPAWFJZFCKF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H15Cl6O4P/c10-1-7(2-11)17-20(16,18-8(3-12)4-13)19-9(5-14)6-15/h7-9H,1-6H2
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| Chemical Name |
tris(1,3-dichloropropan-2-yl) phosphate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Ethanol : ~100 mg/mL (~232.07 mM)
DMSO : ≥ 62.5 mg/mL (~145.05 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 33.33 mg/mL (77.35 mM) in 15% Cremophor EL + 85% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.83 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (4.83 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: ≥ 2.08 mg/mL (4.83 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. Solubility in Formulation 5: 33.33 mg/mL (77.35 mM) in 50% PEG300 50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3207 mL | 11.6036 mL | 23.2072 mL | |
| 5 mM | 0.4641 mL | 2.3207 mL | 4.6414 mL | |
| 10 mM | 0.2321 mL | 1.1604 mL | 2.3207 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT06316609 | ACTIVE, NOT RECRUITING | Other: Gestational Exposure to Emerging Contaminants (ECs) | Atopic Dermatitis | Children's Hospital of Fudan University | 2016-06 |
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