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    TCID
    TCID

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1325
    CAS #: 30675-13-9Purity ≥98%

    Description: TCID (4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione) is a novel and potent DUB (deubiquitinylating enzymes) inhibitor that inhibits ubiquitin C-terminal hydrolase L3 with an IC50 of 0.6 μM.

    References: Chem Biol. 2003 Sep;10(9):837-46; Glia. 2012 Sep;60(9):1356-65. 

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    Molecular Weight (MW)283.92
    FormulaC9H2Cl4O2
    CAS No.30675-13-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 23 mg/mL (81.0 mM)
    Water:<1 mg/mL
    Ethanol: <1 mg/mL
    SMILESO=C(CC1=O)C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl
    Synonyms4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione


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    In Vitro

    In vitro activity: TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods.


    Cell Assay: In transfected MDCK cells, TCID (10 μm for 30 mins) was not able to affect the UCH-L1 inhibitor promoted accumulation of YFP-GLT-1 in intracellular vesicles.

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    References

    Chem Biol. 2003 Sep;10(9):837-46; Glia. 2012 Sep;60(9):1356-65. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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