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    TAK-243
    TAK-243

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4576
    CAS #: 1450833-55-2Purity ≥98%

    Description: TAK-243 (also known as MLN-7243 and AOB-87172) is a novel, potent and selective ubiquitin-like modifier activating enzyme 1 (UBA1; also named as ubiquitin-activating enzyme (UAE)) inhibitor. As a small molecule inhibitor of ubiquitin-activating enzyme (UAE), TAK-243 has potential antineoplastic activity. TAK-243 binds to and inhibits UAE, which prevents both protein ubiquitination and subsequent protein degradation by the proteasome. This results in an excess of proteins in the cells and may lead to endoplasmic reticulum (ER) stress-mediated apoptosis. This inhibits tumor cell proliferation and survival.  

    References: Oncotarget. 2018 Apr 17;9(29):20265-20281.Blood 2017, 130:814.


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    TAK-243

    Name: TAK-243
    CAS#: 1450833-55-2
    Chemical Formula: C19H20F3N5O5S2
    Exact Mass: 519.0858
    Molecular Weight: 519.5142
    Elemental Analysis: C, 43.93; H, 3.88; F, 10.97; N, 13.48; O, 15.40; S, 12.34
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: TAK-243, TAK 243, TAK243, AOB87172, AOB-87172, AOB 87172; MLN7243, MLN-7243, MLN 7243
    IUPAC/Chemical Name: methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate
    InChi Key: PUMGWJMQPGYZFC-IDCJVQTKSA-N
    InChi Code: InChI=1S/C19H20F3N5O5S2/c1-32-34(30,31)26-14-8-13(17(28)18(14)29)24-15-5-6-23-16-9-12(25-27(15)16)10-3-2-4-11(7-10)33-19(20,21)22/h2-7,9,13-14,17-18,24,26,28-29H,8H2,1H3/t13-,14+,17+,18-/m1/s1
    SMILES Code: COS(=O)(=O)N[[email protected]]1C[[email protected]]([[email protected]@H]([[email protected]@H]1O)O)NC2=CC=NC3=CC(=NN23)C4=CC(=CC=C4)SC(F)(F)F


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