| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
In a suspended concentration manner, tacrine hydrochloride (aqueous complex) (12.5 to 37.5 nM) inhibits both human blood butylacetylcholinesterase and venom acetatecholinesterase. AChE from snake venom has an IC50 of 31 nM, while BChE from humans has an IC50 of 25.6 nM[1].
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|---|---|
| ln Vivo |
During reacquisition, administration of tacrine hydrochloride (hydrate) can also change the absolute levels of cocaine self-regulation. Body weight was regained by roughly 0.5% four days following intravenous tacrine hydrochloride hydrate therapy. The osmotic pump conduit method of tacrine hydrochloride (hydrate) does not change the linear or repeated cocaine-induced locomotor activity. During recovery, there was no discernible primary effect or reaction from tacrine hydrochloride (hydrate) therapy on active lever responses. Conditioned place preference was used to measure phosphatase levels, and post hoc comparisons revealed that self-prepared cocaine had much lower levels than phosphoric acid treated with saline [2].
|
| References |
|
| Additional Infomation |
See also: Tacrine Hydrochloride (annotation moved to); Tacrine (annotation moved to).
|
| Molecular Formula |
C13H17CLN2O
|
|---|---|
| Molecular Weight |
252.739882230759
|
| Exact Mass |
252.102
|
| CAS # |
206658-92-6
|
| Related CAS # |
Tacrine hydrochloride;1684-40-8
|
| PubChem CID |
6420002
|
| Appearance |
White to off-white solid powder
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
17
|
| Complexity |
229
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
PXGRMZYJAOQPNZ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C13H14N2.ClH.H2O/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H;1H2
|
| Chemical Name |
1,2,3,4-tetrahydroacridin-9-amine;hydrate;hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~100 mg/mL
DMSO : ~32 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9566 mL | 19.7832 mL | 39.5664 mL | |
| 5 mM | 0.7913 mL | 3.9566 mL | 7.9133 mL | |
| 10 mM | 0.3957 mL | 1.9783 mL | 3.9566 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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