| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
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| ln Vitro |
Sulfachlorazine removal in UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8 systems. The adsorption of sulfachlorazine on the TiO2 surface is weak at pH 7 (<5%). However, it can be efficiently removed using UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8 in ultrapure water systems. Twelve sulfachlorazine by-products were also detected, and the reaction route demonstrated that conduction band electrons were obtained either directly or by the production of superoxide radicals, in addition to ·OH and SO4·− radicals [2].
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|---|---|
| ln Vivo |
Instead of treating systemic infections, sulfachlorazine (60 mg/kg; intravenously or orally; male broiler chicks) is mainly used to treat microbial and parasite gastrointestinal tract infections [1].
|
| Animal Protocol |
Animal/Disease Models: 14 male broiler chickens (30 days old) [1]
Doses: 60 mg/kg Route of Administration: intravenous (iv) (iv)injection or oral administration (pharmacokinetic/PK/PK analysis) Experimental Results: Serum drug concentrations were 0.083, 0.50, 2, and 6 respectively , 24 and 72 hrs (hrs (hours)) after intravenous (iv) (iv)injection, the measured values were 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL respectively. Oral determinations were 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL respectively. |
| References |
[1]. Sentepe I, et al. Pharmacokinetic of sulfaclozine in broiler chickens. Food Chem Toxicol. 2010 Jan;48(1):448-451.
[2]. Ismail L, et al. Effect of water constituents on the degradation of sulfaclozine in the three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. Environ Sci Pollut Res Int. 2018 Jan;25(3):2651-2663. |
| Molecular Formula |
C10H9CLN4O2S
|
|---|---|
| Molecular Weight |
284.7221
|
| Exact Mass |
284.013
|
| CAS # |
102-65-8
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| Related CAS # |
Sulfaclozine sodium;23307-72-4
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| PubChem CID |
66890
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| Appearance |
White to light yellow solid powder
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| Density |
1.6±0.1 g/cm3
|
| Boiling Point |
495.7±55.0 °C at 760 mmHg
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| Flash Point |
253.6±31.5 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
|
| Index of Refraction |
1.683
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| LogP |
1.33
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| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
18
|
| Complexity |
365
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
ClC1C([H])=NC([H])=C(N=1)N([H])S(C1C([H])=C([H])C(=C([H])C=1[H])N([H])[H])(=O)=O
|
| InChi Key |
QKLPUVXBJHRFQZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H9ClN4O2S/c11-9-5-13-6-10(14-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
|
| Chemical Name |
4-amino-N-(6-chloropyrazin-2-yl)benzenesulfonamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 29 mg/mL (~101.85 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.78 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.78 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.78 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5122 mL | 17.5611 mL | 35.1222 mL | |
| 5 mM | 0.7024 mL | 3.5122 mL | 7.0244 mL | |
| 10 mM | 0.3512 mL | 1.7561 mL | 3.5122 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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