| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 250mg | |||
| Other Sizes |
| Targets |
Sulbentine targets fungal cell membranes by inhibiting ergosterol synthesis. As an azole antifungal, it inhibits the enzyme lanosterol 14α-demethylase, which is involved in the synthesis of ergosterol, an essential component of the fungal cell membrane. By inhibiting ergosterol synthesis, sulbentine disrupts the integrity of the fungal cell membrane, leading to cell death. It also inhibits the serotonin transporter (SERT).
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|---|---|
| ln Vitro |
In vitro, sulbentine exhibits antifungal activity against a variety of fungi. It has bacteriostatic (inhibition of bacterial growth) and fungicidal activity. Its mechanism of action involves inhibition of ergosterol synthesis.
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| ln Vivo |
In vivo, sulbentine is used as a locally acting antimycotic. It is used to treat fungal infections of the skin and mucous membranes. It is applied topically.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for sulbentine typically involve evaluating its inhibitory activity against lanosterol 14α-demethylase. The enzyme is incubated with varying concentrations of sulbentine and its substrate. The reaction is monitored by measuring the accumulation of lanosterol or the depletion of ergosterol, and the IC₅₀ is determined.
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| Cell Assay |
For in vitro cell-based assays, sulbentine is dissolved in DMSO and applied to cultured fungal cells at concentrations ranging from 1-100 µg/mL. The Minimum Inhibitory Concentration (MIC) is determined using standard broth dilution methods. The effects on fungal cell growth and membrane integrity are assessed.
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| Animal Protocol |
In vivo animal studies for sulbentine are typically conducted in rodent models of fungal infection. Sulbentine is applied topically at concentrations ranging from 1-10%. Efficacy is evaluated by measuring the reduction in fungal load and the resolution of skin lesions.
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| ADME/Pharmacokinetics |
Sulbentine has a molecular formula of C₁₇H₁₈N₂S₂ and a molecular weight of 314.47 g/mol. It is a white to off-white powder. It is soluble in DMSO and is typically stored at 2-8°C.
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| Toxicity/Toxicokinetics |
Sulbentine is considered to have a manageable toxicity profile for topical use. As a locally acting antimycotic, systemic absorption is limited. Common side effects may include local irritation and hypersensitivity reactions.
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| Additional Infomation |
Dibenzthion is an aromatic amine.
Sulbentine is an azole antifungal agent used for the treatment of fungal infections. It is also known as Dibenzthione. Sulbentine is not approved for clinical use in all countries and is intended for research purposes. It is supplied by various research chemical suppliers for non-human use. |
| Molecular Formula |
C17H18N2S2
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|---|---|
| Molecular Weight |
314.47
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| Exact Mass |
314.091
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| CAS # |
350-12-9
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| PubChem CID |
67686
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.28g/cm3
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| Boiling Point |
451.5ºC at 760mmHg
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| Flash Point |
226.9ºC
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| Index of Refraction |
1.705
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| LogP |
3.813
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
21
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| Complexity |
336
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| Defined Atom Stereocenter Count |
0
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| SMILES |
S=C1SCN(CC2=CC=CC=C2)CN1CC3=CC=CC=C3
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| InChi Key |
QFVAWNPSRQWSDU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H18N2S2/c20-17-19(12-16-9-5-2-6-10-16)13-18(14-21-17)11-15-7-3-1-4-8-15/h1-10H,11-14H2
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| Chemical Name |
3,5-dibenzyl-1,3,5-thiadiazinane-2-thione
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| Synonyms |
NSC150555; NSC 150555; Sulbentine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~318.00 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (19.87 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1800 mL | 15.8998 mL | 31.7995 mL | |
| 5 mM | 0.6360 mL | 3.1800 mL | 6.3599 mL | |
| 10 mM | 0.3180 mL | 1.5900 mL | 3.1800 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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