| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 250mg |
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| 500mg | |||
| Other Sizes |
| Targets |
Sulbenicillin targets penicillin-binding proteins (PBPs) in the bacterial cell wall. As a beta-lactam antibiotic, it inhibits the transpeptidase activity of PBPs, which are enzymes involved in the final stages of bacterial cell wall synthesis. By inhibiting PBPs, sulbenicillin disrupts cell wall cross-linking, leading to cell lysis and death.
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|---|---|
| ln Vitro |
In vitro, sulbenicillin demonstrates antibacterial activity against a number of mucoid and non-mucoid strains of Pseudomonas aeruginosa. It is effective against both Gram-positive and Gram-negative bacteria. It has slightly stronger activity against Pseudomonas aeruginosa and drug-resistant Staphylococcus aureus compared to carbenicillin. It is more stable against beta-lactamases than ampicillin and carbenicillin.
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| ln Vivo |
In vivo, sulbenicillin is used for the treatment of serious infections caused by susceptible bacteria. It is administered parenterally as it is not absorbed orally. It is effective against respiratory and urinary tract infections, septicemia, and other serious infections.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for sulbenicillin typically involve evaluating its inhibitory activity against purified penicillin-binding proteins (PBPs). The compound is incubated with the PBPs, and the inhibition of transpeptidase activity is measured. The Minimum Inhibitory Concentration (MIC) is determined using standard broth dilution methods against various bacterial strains.
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| Cell Assay |
For in vitro cell-based assays, sulbenicillin disodium is dissolved in aqueous buffers and applied to cultured bacterial cells at concentrations ranging from 0.1-100 µg/mL. The MIC is determined using standard methods. The effect on bacterial cell wall synthesis and cell viability is assessed.
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| Animal Protocol |
In vivo animal studies for sulbenicillin are typically conducted in rodent models of bacterial infection. Sulbenicillin is administered intravenously or intramuscularly at doses ranging from 10-100 mg/kg. Efficacy is evaluated by measuring bacterial load in tissues, survival rates, and clinical signs of infection.
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| ADME/Pharmacokinetics |
Sulbenicillin disodium has a molecular formula of C₁₆H₁₆N₂Na₂O₇S₂ and a molecular weight of 458.42 g/mol. It is a white to off-white powder that is soluble in water. It is typically stored as a powder at -20°C.
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| Toxicity/Toxicokinetics |
Sulbenicillin disodium is considered to have a manageable toxicity profile consistent with other penicillins. Common side effects include hypersensitivity reactions, such as skin rashes and anaphylaxis. Gastrointestinal disturbances, including nausea and diarrhea, can occur. No significant hepatotoxicity or nephrotoxicity has been reported.
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| References | |
| Additional Infomation |
Sulbenicillin disodium is an organosodium salt. It contains Sulbenicillin (2-). It is a Semisynthetic penicillin antibiotic.
Sulbenicillin disodium is a penicillin antibiotic used for the treatment of serious infections, particularly those caused by Pseudomonas aeruginosa. It is also known as alpha-sulfobenzylpenicillin disodium. Sulbenicillin disodium is approved for clinical use in some countries. It is supplied by various pharmaceutical and research chemical suppliers for human and research use. |
| Molecular Formula |
C16H16N2NA2O7S2
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|---|---|
| Molecular Weight |
458.41
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| Exact Mass |
458.019
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| CAS # |
28002-18-8
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| PubChem CID |
443984
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
29
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| Complexity |
736
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| Defined Atom Stereocenter Count |
3
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| SMILES |
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C(C3=CC=CC=C3)S(=O)(=O)[O-])C(=O)[O-])C.[Na+].[Na+]
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| InChi Key |
FWRNIJIOFYDBES-HCIBPFAFSA-L
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| InChi Code |
InChI=1S/C16H18N2O7S2.2Na/c1-16(2)11(15(21)22)18-13(20)9(14(18)26-16)17-12(19)10(27(23,24)25)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,17,19)(H,21,22)(H,23,24,25);;/q;2*+1/p-2/t9-,10?,11+,14-;;/m1../s1
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| Chemical Name |
disodium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfonatoacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
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| Synonyms |
Disodium sulbenicillin; alpha-Sulfobenzylpenicillin disodium; Sulbenicillin disodium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~250 mg/mL (~545.35 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (218.14 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1815 mL | 10.9073 mL | 21.8145 mL | |
| 5 mM | 0.4363 mL | 2.1815 mL | 4.3629 mL | |
| 10 mM | 0.2181 mL | 1.0907 mL | 2.1815 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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