| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
In the presence of 1 mM adenosine triphosphate (ATP), SU4984 (5-100 μM; 5 minutes) suppresses the kinase activity of FGFR1K with an IC50 of 10-20 μM [1]. With an IC50 of 20–40 μM, SU4984 (10–90 μM; 5 minutes) prevents aFGF-induced autophosphorylation of FGFR1 in NIH 3T3 cells [1]. 50% less constitutive C2 KIT phosphorylation and a considerable reduction in wild-type receptor tyrosine phosphorylation are observed when SU4984 (5 μM) is used [2]. C2 and P815 cells are killed by SU4984 (1–10 μM; 6 days) [2].
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| References | |
| Additional Infomation |
SU4984 is a substance that inhibits the tyrosine kinase activity of fibroblast growth factor receptor 1, tyrosine phosphorylation of the PDGF receptor and the insulin receptor. (NCI)
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| Molecular Formula |
C20H19N3O2
|
|---|---|
| Molecular Weight |
333.38376
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| Exact Mass |
333.148
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| Elemental Analysis |
C, 72.05; H, 5.74; N, 12.60; O, 9.60
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| CAS # |
186610-89-9
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| PubChem CID |
5941540
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| Appearance |
Yellow solid powder
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| Density |
1.34g/cm3
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| Boiling Point |
649.1ºC at 760 mmHg
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| Flash Point |
346.4ºC
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| Vapour Pressure |
9.81E-17mmHg at 25°C
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| Index of Refraction |
1.72
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| LogP |
3.234
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
25
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| Complexity |
531
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C1/C(=C/C2C=CC(N3CCN(C=O)CC3)=CC=2)/C2C(=CC=CC=2)N1
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| InChi Key |
ZNFJBJDODKHWED-AQTBWJFISA-N
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| InChi Code |
InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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| Chemical Name |
4-[4-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]phenyl]piperazine-1-carbaldehyde
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| Synonyms |
SU 4984; SU4984; SU4984
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~149.98 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 5 mg/mL (15.00 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9996 mL | 14.9979 mL | 29.9958 mL | |
| 5 mM | 0.5999 mL | 2.9996 mL | 5.9992 mL | |
| 10 mM | 0.3000 mL | 1.4998 mL | 2.9996 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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