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    STF-31
    STF-31

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1876
    CAS #: 724741-75-7 Purity ≥98%

    Description: STF-31 is a novel potent and selective glucose transporter (GLUT1) inhibitor with IC50 of 1 μM. STF31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival. Treatment with STF31 inhibits the growth of RCCs by binding GLUT1 directly and impeding glucose uptake in vivo without toxicity to normal tissue. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. 

    References: Sci Transl Med. 2011 Aug 3;3(94):94ra70; ACS Chem Biol. 2014 Oct 17;9(10):2247-54; Stem Cell Reports. 2014 Jun 6;3(1):185-203.

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    Molecular Weight (MW)423.53 
    FormulaC23H25N3O3S 
    CAS No.724741-75-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 85 mg/mL (200.7 mM) 
    Water: <1 mg/mL
    Ethanol: 25 mg/mL (59.0 mM) 
    SMILESO=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2
    SynonymsSTF31; STF-31; STF 31


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    In Vitro

    In vitro activity: STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures.


    Kinase Assay: STF-31 is a novel potent and selective glucose transporter (GLUT1) inhibitor with IC50 of 1 μM. STF31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival. Treatment with STF31 inhibits the growth of RCCs by binding GLUT1 directly and impeding glucose uptake in vivo without toxicity to normal tissue. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. 


    Cell Assay: In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures.

    In VivoIn mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth. 
    Animal modelMice with VHL-deficient RCC xenografts 
    Formulation & DosageDissolved in  DMSO in 16% cremophor EL/PBS; 11.6 mg/kg; i.p. injection 
    ReferencesSci Transl Med. 2011 Aug 3;3(94):94ra70; ACS Chem Biol. 2014 Oct 17;9(10):2247-54; Stem Cell Reports. 2014 Jun 6;3(1):185-203. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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