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    SR-4835
    SR-4835

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V2186
    CAS #: 2387704-62-1Purity ≥98%

    Description: SR-4835 is a novel highly selective dual inhibitor of CDK12 and CDK13, .SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death.  inhibition or loss of CDK12/CDK13 triggers intronic polyadenylation site cleavage that suppresses the expression of core DNA damage response proteins. This provokes a 'BRCAness' phenotype that results in deficiencies in DNA damage repair, promoting synergy with DNA-damaging chemotherapy and PARP inhibitors.


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    Molecular Formula: C21H20Cl2N10O
    Exact Mass: 498.1199
    Molecular Weight: 499.36

    Synonym: SR4835; SR 4835; SR-4835

    Chemical Name: 9H-Purin-6-amine, N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-

    InChi Key: FSELUFUYNUNZKD-UHFFFAOYSA-N

    InChi Code: InChI=1S/C21H20Cl2N10O/c1-31-10-12(8-26-31)33-11-25-18-19(29-21(30-20(18)33)32-2-4-34-5-3-32)24-9-17-27-15-6-13(22)14(23)7-16(15)28-17/h6-8,10-11H,2-5,9H2,1H3,(H,27,28)(H,24,29,30)

    SMILES Code: CN1N=CC(N2C3=NC(N4CCOCC4)=NC(NCC5=NC(C=C(Cl)C(Cl)=C6)=C6N5)=C3N=C2)=C1


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