| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 250mg | |||
| 500mg | |||
| Other Sizes |
| Targets |
SPQ does not have a traditional therapeutic target. It is a fluorescent probe used to measure chloride transport. Its mechanism of action is based on the collisional quenching of its fluorescence by chloride ions. As chloride ions bind to SPQ, the fluorescence intensity decreases, allowing for the measurement of chloride flux across membranes.
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|---|---|
| ln Vitro |
SPQ is not a therapeutic agent with pharmacological in vitro activity. It is a fluorescent probe used in research to study chloride transport mechanisms.
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| ln Vivo |
SPQ is not used as a therapeutic agent in vivo. It is a fluorescent probe used in research applications.
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| Enzyme Assay |
SPQ is not used in enzyme/receptor binding assays as a test compound. It is used as a fluorescent probe in membrane transport studies.
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| Cell Assay |
SPQ is used in cell-based assays to measure chloride transport. Cells are loaded with SPQ, and the fluorescence intensity is measured over time. Changes in fluorescence intensity indicate changes in intracellular chloride concentration, reflecting the activity of chloride channels or transporters.
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| Animal Protocol |
SPQ is not used in animal models as a therapeutic agent. It is a fluorescent probe used in research applications.
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| ADME/Pharmacokinetics |
SPQ (CAS 83907-40-8) has a molecular formula of C13H15NO4S and a molecular weight of 281.33 g/mol. It is also known as 6-Methoxy-N-(3-sulfopropyl)quinolinium. Appearance: typically a solid. Solubility: water and other solvents. Storage: typical for fluorescent dyes (desiccated, protected from light, -20°C). Purity: typically >98% for research use.
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| Toxicity/Toxicokinetics |
No toxicity data is publicly available. As a fluorescent probe used in research, SPQ should be handled with standard laboratory safety precautions. It is not intended for human consumption or therapeutic use.
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| Additional Infomation |
SPQ is a research-grade fluorescent probe, not a drug. It is used to examine and measure membrane chloride transport mechanisms. No clinical trials have been reported.
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| Molecular Formula |
C13H16NO4S+.H2O
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|---|---|
| Molecular Weight |
300.35072
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| Exact Mass |
281.072
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| CAS # |
83907-40-8
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| PubChem CID |
123936
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| Appearance |
White to gray solid powder
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| Melting Point |
299ºC dec.
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| LogP |
2.152
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
19
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| Complexity |
365
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZVDGOJFPFMINBM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H15NO4S/c1-18-12-5-6-13-11(10-12)4-2-7-14(13)8-3-9-19(15,16)17/h2,4-7,10H,3,8-9H2,1H3
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| Chemical Name |
3-(6-methoxyquinolin-1-ium-1-yl)propane-1-sulfonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~25 mg/mL (~88.86 mM)
DMSO : ~1 mg/mL (~3.55 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 10 mg/mL (35.55 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3294 mL | 16.6472 mL | 33.2945 mL | |
| 5 mM | 0.6659 mL | 3.3294 mL | 6.6589 mL | |
| 10 mM | 0.3329 mL | 1.6647 mL | 3.3294 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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