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| 50mg |
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| Targets |
Sodium lauryl sulfoacetate does not have a specific pharmacological target, as it is primarily a surfactant rather than a therapeutic agent. However, its surfactant properties allow it to interact with biological membranes, including viral envelopes. The compound disrupts viral envelope integrity, supporting mechanistic studies of viral entry inhibition. It also acts as an immune adjuvant with anti-immunosuppressive effects. In biological research, sodium lauryl sulfoacetate is used as a reference molecule for preclinical evaluation of envelope-targeting antiviral candidates. Its surfactant properties enable it to solubilize and disperse hydrophobic compounds, making it useful in formulation studies.
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| ln Vitro |
In vitro, sodium lauryl sulfoacetate increases the proliferation of isolated chicken peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 62.5 µg/mL. The compound exhibits surfactant properties that disrupt viral envelope integrity, making it useful for mechanistic studies of viral entry inhibition. It serves as a reference molecule for preclinical evaluation of envelope-targeting antiviral candidates. Sodium lauryl sulfoacetate is used as a foaming agent, emulsifier, wetting agent, detergent, and thickener in various formulations. Its mildness and hard water stability make it suitable for personal care and pharmaceutical applications.
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| ln Vivo |
In vivo, sodium lauryl sulfoacetate is used as a surfactant in veterinary enemas and antiseborrheics. At doses of 1, 2, and 4 mg/kg, it has been studied for its biological effects. The compound is also used as a reference molecule for antiviral research. Its surfactant properties enable it to interact with biological membranes, and it may have applications in topical pharmaceutical formulations. However, detailed in vivo efficacy, pharmacokinetic, and toxicological data for sodium lauryl sulfoacetate are not extensively reported in the available literature. The compound is primarily used in cosmetic, personal care, and research applications.
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| Enzyme Assay |
In vitro enzyme/receptor binding (non-cellular) assays for sodium lauryl sulfoacetate are not standard pharmacological assays, as the compound is primarily a surfactant. However, the compound may be used in biochemical assays as a detergent or solubilizing agent to extract membrane proteins or to disrupt lipid bilayers. Surfactant activity can be measured using surface tension, critical micelle concentration (CMC), or emulsification assays. These assays help characterize the compound's physicochemical properties and its ability to interact with biological membranes. Sodium lauryl sulfoacetate's mildness and hard water stability make it suitable for various formulation studies.
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| Cell Assay |
In vitro cellular experiments with sodium lauryl sulfoacetate are performed to assess its effects on cell proliferation, membrane integrity, and antiviral activity. Chicken peripheral blood mononuclear cells (PBMCs) are cultured and treated with varying concentrations of the compound (e.g., 62.5 µg/mL). Cell proliferation is assessed using MTT or [³H]thymidine incorporation assays. For antiviral studies, cells infected with enveloped viruses are treated with the compound, and viral entry or replication is assessed. The compound's effects on cell membrane integrity may be assessed using lactate dehydrogenase (LDH) release assays or by measuring membrane permeability using fluorescent dyes. Cells are maintained at 37°C in 5% CO₂ with appropriate media supplements.
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| Animal Protocol |
In vivo animal studies with sodium lauryl sulfoacetate have been conducted at doses of 1, 2, and 4 mg/kg. The compound is used as a surfactant in veterinary enemas and antiseborrheics. In research settings, animal studies may assess the compound's safety, tolerability, and efficacy as a surfactant or antiviral agent. Rodents or other animals are administered the compound via topical, oral, or parenteral routes. Parameters assessed include local tolerance, systemic toxicity, and effects on immune function. The compound's surfactant properties and mildness make it suitable for topical pharmaceutical applications.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Sodium dodecyl sulfonate can be absorbed through the skin of guinea pigs. Six weaned female guinea pigs in each of two groups were immersed in either a 0.2% sodium dodecyl sulfonate aqueous solution or distilled water for four hours for three consecutive days. …Seven blood samples were collected before and after each immersion, and 24 hours after the last immersion. …The concentration of sodium dodecyl sulfonate in the blood reached its peak at the end of each immersion and increased with the number of immersions. Pharmacokinetic properties of sodium lauryl sulfoacetate are not extensively characterized, as the compound is primarily a surfactant used in topical and personal care applications rather than a systemic therapeutic agent. The compound has molecular formula C₁₄H₂₇NaO₅S and molecular weight approximately 330. It is a plant-derived solid anionic surfactant. When applied topically, it is expected to remain primarily on the skin surface or in the stratum corneum, with minimal systemic absorption. Storage: 2-8°C. Detailed pharmacokinetic parameters including absorption, distribution, metabolism, and excretion require further investigation from primary research publications. |
| Toxicity/Toxicokinetics |
Toxicological information for sodium lauryl sulfoacetate indicates that it is a mild surfactant that is gentler on the skin than ethoxylated alcohol sulfates. It is used in cosmetics, dentifrices, hair shampoos, rug shampoos, and topical pharmaceuticals. The compound is generally considered safe for topical use at appropriate concentrations. However, as with any surfactant, it may cause skin or eye irritation at high concentrations. Standard safety precautions for handling chemicals apply, including use of personal protective equipment (gloves, safety goggles, lab coat) and working in a well-ventilated area. The compound is for research use only and is not approved for clinical use.
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| References |
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| Additional Infomation |
Sodium dodecyl sulfonate is a wetting agent and surfactant used in enema laxative products.
Drug Indications Sodium dodecyl sulfonate is not an active pharmacological ingredient in pharmaceutical preparations and therefore has no official indications. Sodium lauryl sulfoacetate (CAS 1847-58-1) is an anionic surfactant with molecular formula C₁₄H₂₇NaO₅S and molecular weight approximately 330. It appears as a powder and is a plant-derived solid anionic surfactant. Sodium lauryl sulfoacetate is a mild surfactant that is gentler on the skin than ethoxylated alcohol sulfates and is stable in hard water. It is used as a foaming agent, emulsifier, wetting agent, detergent, and thickener in cosmetics, dentifrices, hair shampoos, rug shampoos, and topical pharmaceuticals. The compound also acts as an immune adjuvant with anti-immunosuppressive effects and has applications in antiviral research as a viral membrane disruptor. Storage: 2-8°C. |
| Molecular Formula |
C14H27NAO5S
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| Molecular Weight |
330.41
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| Exact Mass |
330.147
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| CAS # |
1847-58-1
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| Related CAS # |
151-21-3 (sulfate);1847-58-1 (sulfoacetate);
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| PubChem CID |
23668827
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| Appearance |
White to off-white solid powder
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| LogP |
4.076
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
21
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| Complexity |
338
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
UAJTZZNRJCKXJN-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C14H28O5S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-19-14(15)13-20(16,17)18;/h2-13H2,1H3,(H,16,17,18);/q;+1/p-1
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| Chemical Name |
sodium;2-dodecoxy-2-oxoethanesulfonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~15.62 mg/mL (~47.27 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (6.30 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.30 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.30 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0265 mL | 15.1327 mL | 30.2654 mL | |
| 5 mM | 0.6053 mL | 3.0265 mL | 6.0531 mL | |
| 10 mM | 0.3027 mL | 1.5133 mL | 3.0265 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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