| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
Met4 ubiquitination in yeast cells is inhibited when the cells are exposed to SMER3 (0-60 μM). SMER3 can lessen the growth inhibition of met4Δ cells [1]. Met4 ubiquitination by SCFMet30 was reduced by adding SMER3 to the ligase process in a dose-dependent manner. SMER3 does not change the amounts of Skp1 or Met30 protein, but it strongly inhibits the binding of Met30 to Skp1 [1].
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| References | |
| Additional Infomation |
LSM-42773 is an aromatic ketone.
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| Molecular Formula |
C11H4N4O2
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|---|---|
| Molecular Weight |
224.17
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| Exact Mass |
224.033
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| CAS # |
67200-34-4
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| PubChem CID |
568763
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| Appearance |
Light yellow to green yellow solid powder
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| Density |
1.7±0.1 g/cm3
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| Boiling Point |
437.2±55.0 °C at 760 mmHg
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| Melting Point |
296 °C(dec.)
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| Flash Point |
218.2±31.5 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.779
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| LogP |
0.9
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
17
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| Complexity |
350
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
SFSSAKVWCKFRHE-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
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| Chemical Name |
13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one
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| Synonyms |
SMER3 SMER 3 SMER-3
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~12.5 mg/mL (~55.76 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 1.25 mg/mL (5.58 mM) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4609 mL | 22.3045 mL | 44.6090 mL | |
| 5 mM | 0.8922 mL | 4.4609 mL | 8.9218 mL | |
| 10 mM | 0.4461 mL | 2.2305 mL | 4.4609 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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