| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
SKF-34288 hydrochloride (0.01-1 mM, 48 h) suppresses the growth of C2C12 cells [4]. In C2C12 cells, SKF-34288 hydrochloride (0.25–1 mM, 0–5 days) induces myogenic structure [4]. Pck2 and genes linked to serine biosynthesis have lower mRNA expression when treated with 34288 hydrochloride (0.25 or 1 mM) [4].
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|---|---|
| ln Vivo |
SKF-34288 hydrochloride (37.5-150 mg/kg, Channel) lowers blood pressure and the hunger index [6]. Hydrochloride SKF-34288 (25 mg/kg, SC) counteracts the hypertension caused by albuterol [3]. Intraperitoneal injection of SKF-34288 hydrochloride (30 and 300 mg/kg) lowers pyruvate-induced blood glucose levels of impurities [5].
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| Cell Assay |
Cell Viability Assay[4]
Cell Types: C2C12 cell Tested Concentrations: 0, 0.01, 0.1, 0.25, 0.5, 1 mM Incubation Duration: 48 hrs (hours) Experimental Results: Dose-dependent inhibition of C2C12 cell proliferation. |
| Animal Protocol |
Animal/Disease Models: Starved rats [6]
Doses: 37.5, 75 and 150mg/kg Route of Administration: Oral (po) Experimental Results: demonstrated dose-dependent degree and duration of hypoglycemic effect. |
| References |
| Molecular Formula |
C6H5NO2S.HCL
|
|---|---|
| Molecular Weight |
191.63534
|
| Exact Mass |
190.981
|
| CAS # |
320386-54-7
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| PubChem CID |
24721311
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| Appearance |
Light yellow to yellow solid powder
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| LogP |
1.87
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
11
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| Complexity |
140
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
DYGYEUUVNLEHJP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H5NO2S.ClH/c8-6(9)5-4(10)2-1-3-7-5;/h1-3,10H,(H,8,9);1H
|
| Chemical Name |
3-sulfanylpyridine-2-carboxylic acid;hydrochloride
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~5 mg/mL (~26.09 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 3.33 mg/mL (17.38 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2181 mL | 26.0906 mL | 52.1812 mL | |
| 5 mM | 1.0436 mL | 5.2181 mL | 10.4362 mL | |
| 10 mM | 0.5218 mL | 2.6091 mL | 5.2181 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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