| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg |
|
||
| 10mg |
|
||
| 50mg |
|
||
| Other Sizes |
|
| ln Vitro |
Fizagoprazole (500 μM; 24 hours) suppresses the proliferation of human hepatic stellate cells (HSCs) stimulated by TGF-β (10 ng/mL) [2].
|
|---|---|
| ln Vivo |
In individuals with type 2 diabetes, fizagopra sodium (100 mg/kg/day; gavage commencing at 8–20 weeks of age) dramatically improves eNOS-/-db/db drought tolerance and considerably lowers hyperglycemia [1]. eNOS-/-db/db mice with type 2 diabetes [1]
|
| Cell Assay |
Cell Proliferation Assay[2]
Cell Types: HSCs Tested Concentrations: 250 or 500 µM Incubation Duration: 24 hrs (hours) Experimental Results: Inhibits TGF-β-activated HSCs. Blocks HSCs in the G0/G1 phase without inducing cell trade[2]. proliferation. TGF-β (10 ng/mL) increased HSC proliferation by 10%. Cell Cycle Assay[2] Cell Types: HSC Tested Concentrations: 250 µM, 500 µM Incubation Duration: 24 hrs (hours) Experimental Results: Inhibition of cell cycle progression. |
| Animal Protocol |
Animal/Disease Models: Type 2 diabetes eNOS-/-db/db mice[1]
Doses: 100 mg/kg/day Route of Administration: Given via daily gavage from 8-20 weeks Experimental Results:Compared with vehicle-treated mice, hyperglycemia was markedly diminished, and glucose tolerance was markedly improved. |
| References |
|
| Molecular Formula |
C13H17NAO2
|
|---|---|
| Molecular Weight |
228.26265501976
|
| Exact Mass |
228.112
|
| CAS # |
1254472-97-3
|
| Related CAS # |
Fezagepras;1002101-19-0
|
| PubChem CID |
46944243
|
| Appearance |
White to off-white solid powder
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
16
|
| Complexity |
194
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
CNSJWSLXKSJQFE-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C13H18O2.Na/c1-2-3-4-6-11-7-5-8-12(9-11)10-13(14)15;/h5,7-9H,2-4,6,10H2,1H3,(H,14,15);/q;+1/p-1
|
| Chemical Name |
sodium;2-(3-pentylphenyl)acetate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~438.10 mM)
DMSO : ≥ 64 mg/mL (~280.38 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (9.11 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (9.11 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (9.11 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 120 mg/mL (525.72 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3810 mL | 21.9048 mL | 43.8097 mL | |
| 5 mM | 0.8762 mL | 4.3810 mL | 8.7619 mL | |
| 10 mM | 0.4381 mL | 2.1905 mL | 4.3810 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
