| Size | Price | Stock | Qty |
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| 250mL |
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| 500mL |
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| 1000mL |
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| Other Sizes |
Purity: ≥98%
| Targets |
The biological activities of sesame oil are attributed to its rich content of bioactive components including lignans (sesamin, sesamolin), tocopherols, and polyunsaturated fatty acids. It acts as a potent antioxidant by inhibiting DNA damage and lipid peroxidation. Sesame oil targets oxidative stress pathways by scavenging free radicals and enhancing endogenous antioxidant defenses. It also modulates inflammatory pathways, as demonstrated by its protective effects against lipopolysaccharide (LPS)-stimulated oxidative stress. Its neuroprotective activity is mediated through effects on brain hippocampus in focal cerebral ischemia.
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| ln Vitro |
Rich in Antioxidants: Contains sesamol and sesamin, which fight oxidative stress.
Heart Health: High in unsaturated fats (omega-6 and omega-9), which may help reduce bad cholesterol (LDL). Anti-inflammatory: Compounds like sesamin may reduce inflammation. Nutrient Source: Provides vitamin E, magnesium, calcium, and iron. In vitro, sesame oil demonstrates potent antioxidant activity, inhibiting DNA damage and lipid peroxidation induced by 4-nitroquinoline N-oxide in rats. It shows antitumor activity against malignant melanoma in cell-based studies. The oil exhibits antibacterial and anti-inflammatory activities in various in vitro models. Its ability to protect against oxidative stress in cellular systems is well documented. These in vitro activities support its use as a research tool for studying oxidative stress and inflammation. |
| ln Vivo |
In vivo, sesame oil has demonstrated numerous pharmacological effects. It protects against lipopolysaccharide (LPS)-stimulated oxidative stress in animal models. When given as a dietary supplement, sesame oil exhibits neuroprotective activity on the brain hippocampus of rats in focal cerebral ischemia. It has protective effects against liver damage caused by various agents including cisplatin and acetaminophen. Sesame oil shows antinociceptive and anti-inflammatory activities. It also increases wound healing in SKH1 mice when combined with ozone.
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| Enzyme Assay |
The antioxidant activity of sesame oil is typically assessed using in vitro assays such as DPPH radical scavenging, ABTS, and FRAP. The oil is diluted in suitable solvents (e.g., ethanol or DMSO) at various concentrations and mixed with the radical solution. The decrease in absorbance is measured spectrophotometrically. Lipid peroxidation inhibition is assessed using the thiobarbituric acid reactive substances (TBARS) assay in liver homogenates or liposome models. DNA damage inhibition is evaluated using comet assays or plasmid DNA protection assays.
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| Cell Assay |
For cellular studies, various cell lines (e.g., hepatocytes, neuronal cells, cancer cells) are cultured in appropriate media. Sesame oil is typically emulsified or dissolved in DMSO and diluted in culture media at concentrations ranging from 0.01-1% (v/v). Cells are treated with the oil for 24-72 hours, and cell viability is assessed using MTT or similar assays. ROS levels are measured using DCFH-DA. Inflammatory cytokine production (TNF-α, IL-6) is measured by ELISA. The oil's effects on cell proliferation, apoptosis, and oxidative stress markers are evaluated.
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| Animal Protocol |
In vivo studies for sesame oil are conducted in various rodent models. For neuroprotection studies, rats are subjected to focal cerebral ischemia, and sesame oil is administered as a dietary supplement. For hepatoprotection studies, animals are treated with hepatotoxic agents (cisplatin, acetaminophen) followed by sesame oil administration. For wound healing studies, SKH1 mice receive topical or systemic sesame oil treatment. Endpoints include biochemical markers (serum ALT, AST, MDA, SOD), histopathology, and behavioral assessments. The oil is typically administered via oral gavage, dietary supplementation, or topical application.
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| ADME/Pharmacokinetics |
Specific pharmacokinetic data for sesame oil as a whole are not typically reported due to its complex composition. The oil is absorbed in the gastrointestinal tract and distributed to various tissues. Its bioactive components (lignans, tocopherols) have been studied individually for their PK properties. Sesame oil is commonly used as a delivery vehicle for fat-soluble compounds including steroidal hormones and toxins. Its lipophilic nature facilitates the absorption of co-administered lipophilic drugs. The oil is stable at room temperature and should be stored in a cool, dark place.
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| Toxicity/Toxicokinetics |
Sesame oil is generally recognized as safe for consumption and topical use. It is considered an indirect additive used in food contact substances by the FDA. In research applications, no significant toxicity has been reported at the doses used for efficacy studies. The oil has been shown to protect against liver damage caused by various agents, suggesting hepatoprotective rather than hepatotoxic effects. However, as with any oil, high doses may cause gastrointestinal discomfort. Standard safety precautions should be taken when handling.
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| References |
[1]. Hsu, D.Z., et al. Shock. 2007, 27: 199-204. PMID: 17224796 |
| Additional Infomation |
Extraction Methods:
Cold Press: Made by cold pressing of raw sesame seeds, retaining the light color, mild flavor, and nutrients of sesame. Commonly found in India and the Middle East. Roasting (Asian Style): Made from roasted sesame seeds, resulting in a darker color, a richer nutty aroma, and a fuller flavor. Popular in Chinese, Korean, and Japanese cuisine. Varieties: Light Sesame Oil: Made from raw or lightly roasted sesame seeds; mild flavor, suitable for frying and stir-frying. Dark Sesame Oil: Made from dark roasted sesame seeds; rich flavor, can be used as a seasoning oil or in salad dressings/marinades. Sesame oil is a potent antioxidant that can inhibit DNA damage and lipid peroxidation. It exhibits neuroprotective, anti-inflammatory, antinociceptive, antitumor, and hepatoprotective activities. It accelerates alcohol decomposition in the liver and is used as a vehicle for fat-soluble compounds in research. No clinical trials for therapeutic use exist. For research use only. |
| Molecular Formula |
C7H4FNS2
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|---|---|
| CAS # |
8008-74-0
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.919g/mL
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| Melting Point |
-5 °C
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| Flash Point |
255 °C
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| SMILES |
S1C(NC2C=CC(=CC1=2)F)=S
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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